Metallothionein 3 (MT3) Antibody – Rabbit Polyclonal

This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tissue-specific expression, and contains a threonine insert near its N-terminus and a glutamate-rich hexapeptide insert near its C-terminus relative to the proteins encoded by other gene family members. It plays an important role in zinc and copper homeostasis, and is induced under hypoxic conditions. The encoded protein is a growth inhibitory factor, and reduced levels of the protein are observed in the brains of individuals with some metal-linked neurodegenerative disorders such as Alzheimer's disease. [provided by RefSeq, Sep 2017]

MT3: Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro. Belongs to the metallothionein superfamily. Type 1 family.

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: axon; cytoplasm; cytosol; dendritic spine; extracellular space; inclusion body; intracellular; microtubule; mitochondrial outer membrane; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; ribosome; rough endoplasmic reticulum; synaptic vesicle

Molecular Function: antioxidant activity; cadmium ion binding; caspase inhibitor activity; copper ion binding; drug binding; protein binding; protein kinase activator activity; zinc ion binding

Biological Process: activation of protein kinase B activity; apoptosis; astrocyte development; brain development; cadmium ion homeostasis; cell proliferation; cellular lipid catabolic process; cellular metal ion homeostasis; cellular zinc ion homeostasis; cholesterol catabolic process; energy reserve metabolic process; histone modification; leptin-mediated signaling pathway; negative regulation of apoptosis; negative regulation of autophagy; negative regulation of axon extension; negative regulation of cell growth; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of neuron apoptosis; negative regulation of oxidoreductase activity; negative regulation of transcription, DNA-dependent; positive regulation of catalytic activity; positive regulation of protein phosphorylation; positive regulation of transcription, DNA-templated; positive regulation of vascular endothelial growth factor receptor signaling pathway; protein import into nucleus, translocation; protein kinase B signaling; protein stabilization; regulation of protein amino acid glycosylation; regulation of response to food; removal of superoxide radicals; response to hypoxia; response to metal ion; zinc II ion transport; zinc ion homeostasis