Galanin (GAL) Antibody – Rabbit Polyclonal

This gene encodes a neuroendocrine peptide that is principally produced by a subpopulation of lactotrophs in the pituitary gland. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP). Mice lacking the encoded protein fail to lactate sufficiently due to abnormalities in the expression of prolactin and lactotroph proliferation, exhibit attenuated chronic neuropathic pain and developmental deficits in the dorsal root ganglion neurons. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature proteins. [provided by RefSeq, Jul 2016]

Galanin: Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion. Belongs to the galanin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19 A|19 3.16 cM

Cellular Component: cell soma; cytoplasm; extracellular region; extracellular space; Golgi apparatus; secretory granule

Molecular Function: galanin receptor activity; galanin receptor binding; hormone activity; neuropeptide hormone activity; type 1 galanin receptor binding; type 2 galanin receptor binding; type 3 galanin receptor binding

Biological Process: cAMP-mediated signaling; feeding behavior; inflammatory response; negative regulation of cell proliferation; negative regulation of lymphocyte proliferation; nervous system development; neuropeptide signaling pathway; positive regulation of apoptosis; positive regulation of catagen; positive regulation of cortisol secretion; positive regulation of large conductance calcium-activated potassium channel activity; positive regulation of transcription from RNA polymerase II promoter; protein kinase A signaling; regulation of glucocorticoid metabolic process