Hyaluronoglucosaminidase 2 (HYAL2) Antibody – Rabbit Polyclonal

This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010]

HYAL2: Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. Belongs to the glycosyl hydrolase 56 family.

Protein type: Membrane protein, GPI anchor; Glycan Metabolism - glycosaminoglycan degradation; EC 3.2.1.35; Hydrolase

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: microvillus; cell surface; endoplasmic reticulum; lysosome; cytoplasmic membrane-bound vesicle; cytosol; lipid raft; Golgi membrane; anchored to external side of plasma membrane; anchored to plasma membrane; endocytic vesicle; perinuclear region of cytoplasm; cytoplasm; apical plasma membrane; plasma membrane; cytoplasmic vesicle

Molecular Function: viral receptor activity; protein binding; receptor signaling protein tyrosine kinase inhibitor activity; enzyme binding; transforming growth factor beta binding; hyaluronic acid binding; hyaluronoglucuronidase activity; receptor tyrosine kinase binding; hyalurononglucosaminidase activity

Biological Process: negative regulation of MAP kinase activity; entry of virus into host cell; negative regulation of protein kinase B signaling cascade; glycosaminoglycan metabolic process; response to virus; multicellular organismal aging; pathogenesis; hyaluronan catabolic process; response to antibiotic; glycosaminoglycan catabolic process; response to reactive oxygen species; viral envelope fusion with host membrane; monocyte activation; positive regulation of protein import into nucleus; skeletal morphogenesis; cartilage development; carbohydrate metabolic process; positive regulation of transcription from RNA polymerase II promoter; hemopoietic progenitor cell differentiation; negative regulation of cell growth; kidney development; defense response to virus; hyaluronan metabolic process; positive regulation of inflammatory response; transformation of host cell by virus