Cluster of Differentiation 1d (CD1d) Antibody – Rabbit Polyclonal

This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

CD1D: Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.

Protein type: Apoptosis; Cell surface; Lipid-binding; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: basolateral plasma membrane; cell surface; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; endosome membrane; integral component of plasma membrane; lysosomal membrane; plasma membrane

Molecular Function: beta-2-microglobulin binding; cell adhesion molecule binding; endogenous lipid antigen binding; exogenous lipid antigen binding; histone binding; lipid antigen binding; receptor activity

Biological Process: antigen processing and presentation, endogenous lipid antigen via MHC class Ib; antigen processing and presentation, exogenous lipid antigen via MHC class Ib; detection of bacterium; heterotypic cell-cell adhesion; innate immune response; positive regulation of innate immune response; positive regulation of T cell proliferation; regulation of immune response; T cell selection; viral process