Signal Transducer and Activator of Transcription 1 (STAT1) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

STAT1: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2q32.2

Cellular Component: axon; cytoplasm; cytosol; dendrite; nuclear chromatin; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein complex

Molecular Function: cadherin binding; CCR5 chemokine receptor binding; DNA binding transcription factor activity; double-stranded DNA binding; enzyme binding; histone acetyltransferase binding; histone binding; identical protein binding; nuclear hormone receptor binding; promoter-specific chromatin binding; protein binding; protein homodimerization activity; protein phosphatase 2A binding; signal transducer activity; tumor necrosis factor receptor binding; ubiquitin-like protein ligase binding

Biological Process: apoptosis; blood circulation; cellular response to insulin stimulus; cellular response to interferon-gamma; cellular response to organic cyclic compound; defense response to virus; endothelial cell migration; JAK-STAT cascade; macrophage derived foam cell differentiation; metanephric mesenchymal cell differentiation; metanephric mesenchymal cell proliferation involved in metanephros development; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of metanephric nephron tubule epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of viral protein levels in host cell; positive regulation of defense response to virus by host; positive regulation of erythrocyte differentiation; positive regulation of interferon-alpha production; positive regulation of mesenchymal cell proliferation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of apoptosis; response to cAMP; response to cytokine; response to drug; response to hydrogen peroxide; response to mechanical stimulus; response to nutrient; response to peptide hormone; transcription, DNA-dependent; tumor necrosis factor-mediated signaling pathway; viral process

Disease: Immunodeficiency 31a; Immunodeficiency 31b; Immunodeficiency 31c