Protein Interacting with Protein Kinase C Alpha 1 (PICK1) Antibody – Rabbit Polyclonal

PICK1: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel.

Protein type: Adaptor/scaffold; Cell development/differentiation; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: 15|15 E1

Cellular Component: aggresome; cell junction; cytoplasm; cytoskeleton; cytosol; dendrite; Golgi apparatus; membrane; mitochondrion; neuron projection; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; postsynaptic early endosome; postsynaptic membrane; presynaptic membrane; protein complex; synapse; synaptic vesicle

Molecular Function: actin binding; actin filament binding; Arp2/3 complex binding; cytoskeletal protein binding; enzyme binding; G-protein coupled receptor binding; identical protein binding; ionotropic glutamate receptor binding; metal ion binding; protein binding; protein C-terminus binding; protein domain specific binding; protein kinase C binding; receptor binding; SNAP receptor activity

Biological Process: cellular response to glucose starvation; glial cell development; monoamine transport; multicellular organism development; negative regulation of gene expression; positive regulation of receptor internalization; protein amino acid phosphorylation; protein homooligomerization; protein kinase C-activating G-protein coupled receptor signaling pathway; protein targeting; receptor clustering; regulation of synapse structure or activity