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Serum/Glucocorticoid Regulated Kinase 3 (SGK3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2016885
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MBS2016885 is an antibody targeting SGK3. Also known as Polyclonal Antibody to Serum/Glucocorticoid Regulated Kinase 3 (SGK3). Reactive in Mouse, Human, Rat. Host: Rabbit. More details

$215 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Serum/Glucocorticoid Regulated Kinase 3 (SGK3), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Serum/Glucocorticoid Regulated Kinase 3 (SGK3)
Product Gene Name
anti-SGK3 antibody
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- HSTSRNINLG PTGNPHAKPT DFDFLKVIGK GSFGKVLLAK RKLDGKFYAV KVLQKKIVLN RKEQKHIMAE RNVLLKNVKH PFLVGLHYSF QTTEKLYFVL DFVNGGELFF HLQRERSFPE PRARFYAAEI ASALGYLHSI KIVYRDLKPE NILLDSMGHV VLTDFGLCKE GIAISDTTTT FCGTPEYLAP EVIRKQPYDN
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Human, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against SGK3. It has been selected for its ability to recognize SGK3 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: SGK3 (MBS2016885)
Immunogen: SGK3 (MBS2018566)
Matching Pairs
Unconjugated Antibody: SGK3 (MBS2016885)
APC-CY7 Conjugated Antibody: SGK3 (MBS2074712)
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Molecular Weight
57,145 Da
3D Structure
ModBase 3D Structure for Q9ERE3
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant SGK3 (His141~Glu368) expressed in E.coli.
Cross Reactivity
Mouse
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2074714
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-SGK3 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-SGK3 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-SGK3 antibody

Western Blot: Sample: Mouse Liver lysate; Primary Ab: 2ug/ml Rabbit Anti-Mouse SGK3 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
Rabbit Anti-SGK3 Polyclonal Antibody – Cat# MBS2016885

Western Blot (WB) of anti-SGK3 antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-SGK3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS2016885

Immunohistochemistry (IHC) of anti-SGK3 antibody

DAB staining on fromalin fixed paraffin-embedded Spleen tissue)
Rabbit Anti-SGK3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2016885

Immunohistochemistry (IHC) of anti-SGK3 antibody

DAB staining on IHC-P; Samples: Mouse Liver Tissue)
Rabbit Anti-SGK3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2016885

Other Notes

Small volumes of anti-SGK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SGK3. It may not necessarily be applicable to this product.

NCBI GI #
83649757
NCBI GeneID
170755
NCBI Accession #
NP_001032848.1
UniProt Primary Accession #
Q9ERE3
UniProt Secondary Accession #
Q3UAY2
UniProt Related Accession #
Q9ERE3
GenBank Nucleotide #
NM_001037759.1
NCBI Official Full Name
serine/threonine-protein kinase Sgk3
NCBI Official Synonym Full Names
serum/glucocorticoid regulated kinase 3
NCBI Official Symbol
Sgk3
NCBI Official Synonym Symbols
fy; fz; Cisk; 2510015P22Rik; A330005P07Rik
UniProt Protein Name
Serine/threonine-protein kinase Sgk3
UniProt Synonym Protein Names
Cytokine-independent survival kinase; Serum/glucocorticoid-regulated kinase 3; Serum/glucocorticoid-regulated kinase-like
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
Sgk3
UniProt Synonym Gene Names
Cisk; Sgkl
NCBI Protein Information
serine/threonine-protein kinase Sgk3

UniProt Comments for SGK3

Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na+ channels: SCNN1A/ENAC and SCN5A, K+ channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca2+ channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na+/dicarboxylate cotransporter: SLC13A2/NADC1, Na+-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na+/H+ exchanger: SLC9A3/NHE3, and the Na+/K+ ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.
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Research Articles on SGK3

1. SGK1 and SGK3 are expressed in multiple microglial cell lines. SGK1 and SGK3 may play an important role in regulating microglial viability and inflammatory responses.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-SGK3 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >5 publications with SGK3 and Kidney Diseases
 Urologic Diseases Antibodies  >4 publications with SGK3 and Urologic Diseases
 Neoplasms Antibodies  >3 publications with SGK3 and Neoplasms
 Cardiovascular Diseases Antibodies  >2 publications with SGK3 and Cardiovascular Diseases
 Hypertension Antibodies  >2 publications with SGK3 and Hypertension
 Breast Neoplasms Antibodies  >2 publications with SGK3 and Breast Neoplasms
 Fibrosis Antibodies  >1 publications with SGK3 and Fibrosis
 Disease Models, Animal Antibodies  >1 publications with SGK3 and Disease Models, Animal
 Heart Diseases Antibodies  >1 publications with SGK3 and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >1 publications with SGK3 and Arrhythmias, Cardiac

Organs/Tissues associated with anti-SGK3 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >17 publications with SGK3 and Kidney
 Brain Antibodies  >10 publications with SGK3 and Brain
 Skin Antibodies  >5 publications with SGK3 and Skin
 Bone Antibodies  >3 publications with SGK3 and Bone
 Embryonic Tissue Antibodies  >3 publications with SGK3 and Embryonic Tissue
 Liver Antibodies  >2 publications with SGK3 and Liver
 Pancreas Antibodies  >2 publications with SGK3 and Pancreas
 Inner Ear Antibodies  >2 publications with SGK3 and Inner Ear
 Connective Tissue Antibodies  >1 publications with SGK3 and Connective Tissue
 Eye Antibodies  >1 publications with SGK3 and Eye
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