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Thyrotropin Releasing Hormone (TRH) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2016918
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MBS2016918 is an antibody targeting TRH. Also known as FITC-linked Antibody to Thyrotropin Releasing Hormone (TRH). Reactive in Mouse. Host: Rabbit. More details

$250 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Thyrotropin Releasing Hormone (TRH), Polyclonal Antibody
Full Product Name
FITC-linked Antibody to Thyrotropin Releasing Hormone (TRH)
Product Gene Name
anti-TRH antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as solution form in PBS , pH 8, 1% BSA ,50% glycerol; 0.05% Proclin-300.
Purity/Purification
Antigen-specific Affinity Chromatography.
Concentration
1mg/ml (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Keep in dark place
Aliquot and store at 4 degree C for 12 months.

Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.
Matching Pairs
Unconjugated Antibody: TRH (MBS2005590)
FITC Conjugated Antibody: TRH (MBS2016918)
Matching Pairs
FITC Conjugated Antibody: TRH (MBS2016918)
Immunogen: TRH (MBS2086307)
Chromosome Location
Chromosome: 3; NC_000003.11 (129693236..129696781). Location: 3q13.3-q21
OMIM
613879
3D Structure
ModBase 3D Structure for P20396
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Antibody labeling
Label
FITC
Unconjugated Antibody
MBS2005590
Traits
Liquid
Immunogen
Synthetic Peptide, TRH conjugated to OVA ( MBS2086307 ). Target peptide sequence: QHP

Product Categories/Family for anti-TRH antibody

FITC Antibody
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-TRH antibody
Immunohistochemistry (IHC); Immunocytochemistry (ICC); Immunofluorescence (IF).
Application Notes for anti-TRH antibody
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.

Other Notes

Small volumes of anti-TRH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TRH. It may not necessarily be applicable to this product.

NCBI GI #
6005920
NCBI GeneID
7200
NCBI Accession #
NP_009048.1
UniProt Primary Accession #
P20396
UniProt Secondary Accession #
Q2TB83; B2R8R1
UniProt Related Accession #
P20396
GenBank Nucleotide #
NM_007117.4
NCBI Official Full Name
thyrotropin releasing hormone preproprotein
NCBI Official Synonym Full Names
thyrotropin-releasing hormone
NCBI Official Symbol
TRH
NCBI Official Synonym Symbols
TRF; Pro-TRH
UniProt Protein Name
Pro-thyrotropin-releasing hormone
UniProt Synonym Protein Names
ProthyroliberinCleaved into the following chain:Thyrotropin-releasing hormone; TRH; Alternative name(s):; Protirelin; TSH-releasing factor; Thyroliberin; Thyrotropin-releasing factor
Protein Family
Pro-thyrotropin-releasing hormone
UniProt Gene Name
TRH
UniProt Synonym Gene Names
Pro-TRH; TRH; TRF
NCBI Protein Information
thyrotropin releasing hormone; protirelin; prothyroliberin; TSH-releasing factor; thyrotropin-releasing factor; pro-thyrotropin-releasing hormone

NCBI Summary for TRH

This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]
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UniProt Comments for TRH

TRH: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes. Belongs to the TRH family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q13.3-q21

Cellular Component: extracellular region; plasma membrane; nucleus; secretory granule

Molecular Function: neuropeptide hormone activity; thyrotropin-releasing hormone activity

Biological Process: hormone-mediated signaling; negative regulation of glutamate secretion; eating behavior; positive regulation of insulin secretion; histamine metabolic process; signal transduction; adult walking behavior; response to ethanol; cell-cell signaling; response to hypoxia; response to glucose stimulus; response to cold; response to corticosterone stimulus; positive regulation of gamma-aminobutyric acid secretion

Disease: Thyrotropin-releasing Hormone Deficiency
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Research Articles on TRH

1. TRH, LH-RH and substance P are not affected in Alzheimer disease and Down's syndrome.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TRH antibody

 Reference Product  PubMed Publications
 PRL antibody  >1753 publications with TRH and PRL
 GHRH antibody  >252 publications with TRH and GHRH
 CCK antibody  >63 publications with TRH and CCK
 TRHR antibody  >47 publications with TRH and TRHR
 NTS antibody  >16 publications with TRH and NTS
 GRP antibody  >8 publications with TRH and GRP
 GCG antibody  >2 publications with TRH and GCG
 GNRH1 antibody  >1 publications with TRH and GNRH1

Pathways associated with anti-TRH antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Thyroxine (Thyroid Hormone) Production Pathway antibodies  Thyroxine (Thyroid Hormone) Production Pathway Diagram

Diseases associated with anti-TRH antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1994 publications with TRH and Nervous System Diseases
 Brain Diseases Antibodies  >1679 publications with TRH and Brain Diseases
 THYROTROPIN-RELEASING HORMONE DEFICIENCY Antibodies  >285 publications with TRH and THYROTROPIN-RELEASING HORMONE DEFICIENCY
 Disease Models, Animal Antibodies  >131 publications with TRH and Disease Models, Animal
 Bipolar Disorder Antibodies  >102 publications with TRH and Bipolar Disorder
 Seizures Antibodies  >94 publications with TRH and Seizures
 Hypertension Antibodies  >93 publications with TRH and Hypertension
 Hypothermia Antibodies  >91 publications with TRH and Hypothermia
 Pain Antibodies  >84 publications with TRH and Pain
 Movement Disorders Antibodies  >60 publications with TRH and Movement Disorders

Organs/Tissues associated with anti-TRH antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4641 publications with TRH and Brain
 Ovary Antibodies  >124 publications with TRH and Ovary
 Lung Antibodies  >113 publications with TRH and Lung
 Eye Antibodies  >110 publications with TRH and Eye
 Pineal Gland Antibodies  >48 publications with TRH and Pineal Gland
 Bone Marrow Antibodies  >12 publications with TRH and Bone Marrow
 Cervix Antibodies  >3 publications with TRH and Cervix
 Uncharacterized Tissue Antibodies  >1 publications with TRH and Uncharacterized Tissue
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