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Nucleoporin 98kDa (NUP98) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2017046
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MBS2017046 is an antibody targeting NUP98. Also known as Polyclonal Antibody to Nucleoporin 98kDa (NUP98). Reactive in Mouse. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Nucleoporin 98kDa (NUP98), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Nucleoporin 98kDa (NUP98)
Product Gene Name
anti-NUP98 antibody
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- TGT AKSHLFDGLD DDEPSLANGA FMPKKSIKKL VLKNLNNSNL FSPVNHDSED LASPSEYPEN GERFSFLSKP VDENNQQDGE DDSLVSRFYT NPIAKPIPQT PESVGNKNNS SSNVEDTIVA LNMRAALRNG LEGSSEETSF HDESLQDDRE EIENNAYHIH PAGIVLTKVG YYTIPSMDDL AKITNEKGEC
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against NUP98. It has been selected for its ability to recognize NUP98 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: NUP98 (MBS2017046)
Immunogen: NUP98 (MBS2018216)
Matching Pairs
Unconjugated Antibody: NUP98 (MBS2017046)
APC-CY7 Conjugated Antibody: NUP98 (MBS2052383)
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Molecular Weight
197,241 Da
3D Structure
ModBase 3D Structure for Q6PFD9
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant NUP98 (Thr568~Tyr776) expressed in E.coli.
Cross Reactivity
Mouse
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2052385
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-NUP98 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-NUP98 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-NUP98 antibody

Western Blot: Sample: Mouse Serum; Primary Ab: 1ug/ml Rabbit Anti-Mouse NUP98 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
Rabbit Anti-NUP98 Polyclonal Antibody – Cat# MBS2017046

Western Blot (WB) of anti-NUP98 antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-NUP98 Polyclonal Antibody, Western Blot (WB) – Cat# MBS2017046

Immunohistochemistry (IHC) of anti-NUP98 antibody

DAB staining on fromalin fixed paraffin-embedded Brain tissue)
Rabbit Anti-NUP98 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2017046

Other Notes

Small volumes of anti-NUP98 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NUP98. It may not necessarily be applicable to this product.

NCBI GI #
562151654
NCBI GeneID
269966
NCBI Accession #
NP_001274093.1
UniProt Primary Accession #
Q6PFD9
UniProt Secondary Accession #
Q68G59
UniProt Related Accession #
Q6PFD9
GenBank Nucleotide #
NM_001287164.1
NCBI Official Full Name
nuclear pore complex protein Nup98-Nup96 isoform 1
NCBI Official Synonym Full Names
nucleoporin 98
NCBI Official Symbol
Nup98
NCBI Official Synonym Symbols
Nup96; AI849286; 4732457F17
UniProt Protein Name
Nuclear pore complex protein Nup98-Nup96
UniProt Synonym Protein Names
Nuclear pore complex protein Nup98Alternative name(s):98 kDa nucleoporin; Nucleoporin Nup98; Nup98
UniProt Gene Name
Nup98
UniProt Synonym Gene Names
Nup98; Nup96
NCBI Protein Information
nuclear pore complex protein Nup98-Nup96

UniProt Comments for NUP98

NUP98: Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The repeat domain in Nup98 has a direct role in the transport. Nup98 interacts directly with Nup96. Nup96 is part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus. May interact with RAE1. Interacts with vesicular stomatitis virus protein M. Belongs to the nucleoporin GLFG family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Nucleoporin

Chromosomal Location of Human Ortholog: 7 E2|7 54.71 cM

Cellular Component: intracellular membrane-bound organelle; intracellular ribonucleoprotein complex; kinetochore; membrane; nuclear body; nuclear envelope; nuclear inclusion body; nuclear membrane; nuclear pore; nucleoplasm; nucleus

Molecular Function: hydrolase activity; mRNA binding; nuclear localization sequence binding; nucleocytoplasmic transporter activity; peptidase activity; peptide binding; RNA binding; serine-type peptidase activity; structural constituent of nuclear pore

Biological Process: DNA replication; mRNA transport; nuclear pore complex assembly; positive regulation of mRNA splicing, via spliceosome; protein import into nucleus; protein transport; proteolysis; RNA export from nucleus; transport
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Research Articles on NUP98

1. We demonstrated that Nup98-TopIIbeta and Nup98-SETBP1 negatively regulate the XPO1-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98-fusion proteins induce tumorigenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NUP98 antibody

 Reference Product  PubMed Publications
 Nup153 antibody  >33 publications with NUP98 and Nup153
 Rae1 antibody  >26 publications with NUP98 and Rae1
 Nup62 antibody  >16 publications with NUP98 and Nup62
 Nup107 antibody  >8 publications with NUP98 and Nup107
 Nxf1 antibody  >4 publications with NUP98 and Nxf1
 Nup133 antibody  >3 publications with NUP98 and Nup133
 Sec13 antibody  >3 publications with NUP98 and Sec13
 Xpo1 antibody  >1 publications with NUP98 and Xpo1

Pathways associated with anti-NUP98 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Glucose Transport Pathway antibodies  Glucose Transport Pathway Diagram
 Hexose Transport Pathway antibodies  Hexose Transport Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram

Diseases associated with anti-NUP98 antibody

 Disease Name  Pubmed Publications
 Leukemia, Myeloid, Acute Antibodies  >165 publications with NUP98 and Leukemia, Myeloid, Acute
 Immune System Diseases Antibodies  >22 publications with NUP98 and Immune System Diseases
 Growth Disorders Antibodies  >3 publications with NUP98 and Growth Disorders
 Hemorrhage Antibodies  >2 publications with NUP98 and Hemorrhage
 Lung Neoplasms Antibodies  >1 publications with NUP98 and Lung Neoplasms
 Breast Neoplasms Antibodies  >1 publications with NUP98 and Breast Neoplasms
 Liver Diseases Antibodies  >1 publications with NUP98 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with NUP98 and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >1 publications with NUP98 and Cardiovascular Diseases
 Hyperplasia Antibodies  >1 publications with NUP98 and Hyperplasia

Organs/Tissues associated with anti-NUP98 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >78 publications with NUP98 and Bone Marrow
 Thymus Antibodies  >3 publications with NUP98 and Thymus
 Eye Antibodies  >2 publications with NUP98 and Eye
 Ovary Antibodies  >2 publications with NUP98 and Ovary
 Embryonic Tissue Antibodies  >2 publications with NUP98 and Embryonic Tissue
 Brain Antibodies  >1 publications with NUP98 and Brain
 Mammary Gland Antibodies  >1 publications with NUP98 and Mammary Gland
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