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Myeloproliferative Leukemia Virus Oncogene (MPL) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2017492
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MBS2017492 is an antibody targeting MPL. Also known as Polyclonal Antibody to Myeloproliferative Leukemia Virus Oncogene (MPL). Reactive in Mus musculus (Mouse). Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Myeloproliferative Leukemia Virus Oncogene (MPL), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Myeloproliferative Leukemia Virus Oncogene (MPL)
Product Gene Name
anti-MPL antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mus musculus (Mouse)
Form/Format
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
0.5mg/mL (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.

Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: MPL (MBS2017492)
Immunogen: MPL (MBS2018696)
Matching Pairs
Unconjugated Antibody: MPL (MBS2017492)
APC-CY7 Conjugated Antibody: MPL (MBS2055531)
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3D Structure
ModBase 3D Structure for Q08351
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Polyclonal antibody preparation
Traits
Liquid
Cross Reactivity
Human
Immunogen
Recombinant TPOR (Leu66~Ser260) expressed in E.coli (MBS2018696).
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-MPL antibody
Immunohistochemistry (IHC)
Application Notes for anti-MPL antibody
Immunohistochemistry: 5-20ug/mL;
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-MPL antibody

Western Blot:
Sample: Human Hela Cells.
Rabbit Anti-MPL Polyclonal Antibody – Cat# MBS2017492

Western Blot (WB) of anti-MPL antibody

Western Blot:
Sample: Recombinant MPL, Mouse.
Rabbit Anti-MPL Polyclonal Antibody, Western Blot (WB) – Cat# MBS2017492

Immunohistochemistry (IHC) of anti-MPL antibody

DAB staining on IHC-P;
Samples: Mouse Lung Tissue
Rabbit Anti-MPL Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2017492

Immunohistochemistry (IHC) of anti-MPL antibody

DAB staining on IHC-P;
Samples: Mouse Pancreas Tissue.
Rabbit Anti-MPL Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2017492

Immunohistochemistry (IHC) of anti-MPL antibody

DAB staining on IHC-P;
Samples: Mouse Lung Tissue;
Primary Ab: 10ug/ml Rabbit Anti-Mouse MPL Antibody
Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-MPL Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2017492

Immunohistochemistry (IHC) of anti-MPL antibody

Vector Red staining on IHC-P;
Samples: Human Placenta Tissue;
Primary Ab: 20ug/ml Rabbit Anti-Human MPL Antibody
Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
Rabbit Anti-MPL Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2017492

Immunohistochemistry (IHC) of anti-MPL antibody

Vector Red staining on IHC-P; Samples: Human Spleen Tissue; Primary Ab: 20ug/ml Rabbit Anti-Human MPL Antibody
Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
Rabbit Anti-MPL Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2017492

Other Notes

Small volumes of anti-MPL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MPL. It may not necessarily be applicable to this product.

NCBI GI #
171846242
NCBI GeneID
17480
NCBI Accession #
NP_001116421.1
UniProt Primary Accession #
Q08351
UniProt Secondary Accession #
Q8BRX0; A6H8H6
UniProt Related Accession #
Q08351
GenBank Nucleotide #
NM_001122949.2
NCBI Official Full Name
thrombopoietin receptor isoform 1
NCBI Official Synonym Full Names
myeloproliferative leukemia virus oncogene
NCBI Official Symbol
Mpl
NCBI Official Synonym Symbols
CD110; TPO-R; c-mpl; hlb219
UniProt Protein Name
Thrombopoietin receptor
UniProt Synonym Protein Names
Myeloproliferative leukemia protein; Proto-oncogene c-Mpl; CD_antigen: CD110
Protein Family
Thrombopoietin receptor
UniProt Gene Name
Mpl
UniProt Synonym Gene Names
Tpor; TPO-R
NCBI Protein Information
thrombopoietin receptor

UniProt Comments for MPL

MPL: a hematopoietic receptor for thrombopoietin. Thrombopoietin is the major regulator of megakaryocytopoiesis and platelet formation. Dimerizes upon binding of thrombopoietin, leading to its phosphorylation and activation of JAKs and STATs. May represent a regulatory molecule specific for TPO-R-dependent immune responses. Two splice-variant isoforms have been described.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 4 D2.1|4 54.61 cM

Cellular Component: cell soma; cell surface; Golgi apparatus; integral component of membrane; membrane; neuron projection; plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; thrombopoietin receptor activity

Biological Process: basophil homeostasis; eosinophil homeostasis; homeostasis of number of cells; negative regulation of apoptosis; neutrophil homeostasis; platelet formation; positive regulation of gene expression; positive regulation of lymphocyte proliferation; positive regulation of platelet formation; regulation of chemokine production; regulation of stem cell division; regulation of stem cell proliferation
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Research Articles on MPL

1. these results demonstrate that MPL P106L is a receptor with an incomplete defect in trafficking.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MPL antibody

 Reference Product  PubMed Publications
 Jak2 antibody  >498 publications with MPL and Jak2
 Cbl antibody  >37 publications with MPL and Cbl
 Thpo antibody  >34 publications with MPL and Thpo
 Gata1 antibody  >28 publications with MPL and Gata1
 Runx1 antibody  >23 publications with MPL and Runx1
 Jak1 antibody  >19 publications with MPL and Jak1
 Tyk2 antibody  >17 publications with MPL and Tyk2
 Jak3 antibody  >10 publications with MPL and Jak3
 Stat5a antibody  >7 publications with MPL and Stat5a
 Shc1 antibody  >5 publications with MPL and Shc1

Pathways associated with anti-MPL antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 PluriNetWork Pathway antibodies  PluriNetWork Pathway Diagram

Diseases associated with anti-MPL antibody

 Disease Name  Pubmed Publications
 Thrombocythemia, Essential Antibodies  >270 publications with MPL and Thrombocythemia, Essential
 Thrombocytosis Antibodies  >257 publications with MPL and Thrombocytosis
 Leukemia, Myeloid Antibodies  >195 publications with MPL and Leukemia, Myeloid
 Leukemia, Myeloid, Acute Antibodies  >133 publications with MPL and Leukemia, Myeloid, Acute
 Cardiovascular Diseases Antibodies  >109 publications with MPL and Cardiovascular Diseases
 Myelodysplastic Syndromes Antibodies  >75 publications with MPL and Myelodysplastic Syndromes
 Chromosome Aberrations Antibodies  >68 publications with MPL and Chromosome Aberrations
 Necrosis Antibodies  >66 publications with MPL and Necrosis
 Inflammation Antibodies  >60 publications with MPL and Inflammation
 Respiratory Tract Diseases Antibodies  >56 publications with MPL and Respiratory Tract Diseases

Organs/Tissues associated with anti-MPL antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >472 publications with MPL and Bone Marrow
 Spleen Antibodies  >126 publications with MPL and Spleen
 Mammary Gland Antibodies  >5 publications with MPL and Mammary Gland
 Inner Ear Antibodies  >1 publications with MPL and Inner Ear
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