Caveolin 1 (CAV1) Antibody – Rabbit Polyclonal

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]

caveolin-1: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4. Interacts (via the N- terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with BMX and BTK. Expressed in muscle and lung, less so in liver, brain and kidney. Belongs to the caveolin family. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 7q31.2

Cellular Component: acrosomal membrane; caveola; cell cortex; cilium; cytoplasmic vesicle; early endosome membrane; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; focal adhesion; Golgi membrane; integral component of plasma membrane; intracellular; lipid droplet; membrane; membrane raft; perinuclear region of cytoplasm; plasma membrane; protein complex

Molecular Function: ATPase binding; cholesterol binding; enzyme binding; identical protein binding; inward rectifier potassium channel inhibitor activity; ion channel binding; nitric-oxide synthase binding; patched binding; protease activator activity; protein binding; protein binding, bridging; protein complex scaffold activity; protein heterodimerization activity; protein kinase binding; Rac GTPase binding; receptor binding; structural molecule activity

Biological Process: angiogenesis; angiotensin-activated signaling pathway involved in heart process; beta-catenin destruction complex disassembly; calcium ion homeostasis; calcium ion transport; caveolin-mediated endocytosis; cellular calcium ion homeostasis; cellular response to exogenous dsRNA; cellular response to hyperoxia; cellular response to peptide hormone stimulus; cellular response to transforming growth factor beta stimulus; cholesterol homeostasis; cholesterol transport; inactivation of MAPK activity; lactation; leukocyte migration; lipid storage; maintenance of cellular protein localization; mammary gland development; mammary gland involution; membrane depolarization; negative regulation of anoikis; negative regulation of canonical Wnt signaling pathway; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of endothelial cell proliferation; negative regulation of epithelial cell differentiation; negative regulation of JAK-STAT cascade; negative regulation of MAPKKK cascade; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric-oxide synthase activity; negative regulation of peptidyl-serine phosphorylation; negative regulation of peptidyl-tyrosine autophosphorylation; negative regulation of pinocytosis; negative regulation of potassium ion transmembrane transport; negative regulation of protein binding; negative regulation of protein ubiquitination; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of tyrosine phosphorylation of STAT protein; nitric oxide homeostasis; positive regulation of calcium ion transport into cytosol; positive regulation of canonical Wnt signaling pathway; positive regulation of catalytic activity; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of gene expression; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of peptidase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of protein ubiquitination; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of vasoconstriction; posttranscriptional regulation of gene expression; protein homooligomerization; protein localization; receptor internalization; receptor internalization involved in canonical Wnt signaling pathway; receptor-mediated endocytosis of virus by host cell; regulation of blood coagulation; regulation of cardiac muscle cell action potential involved in regulation of contraction; regulation of cytosolic calcium ion concentration; regulation of entry of bacterium into host cell; regulation of fatty acid metabolic process; regulation of heart rate by cardiac conduction; regulation of membrane repolarization during action potential; regulation of nitric-oxide synthase activity; regulation of peptidase activity; regulation of ruffle assembly; regulation of smooth muscle contraction; regulation of the force of heart contraction by chemical signal; regulation of ventricular cardiac muscle cell action potential; response to bacterium; response to calcium ion; response to estrogen; response to hypoxia; response to progesterone; skeletal muscle tissue development; T cell costimulation; triacylglycerol metabolic process; vasculogenesis; vasoconstriction; vesicle organization and biogenesis

Disease: Lipodystrophy, Congenital Generalized, Type 3; Partial Lipodystrophy, Congenital Cataracts, And Neurodegeneration Syndrome; Pulmonary Hypertension, Primary, 3