Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 (CEACAM1) Antibody – Mouse Monoclonal

CEACAM1: carcinoembryonic antigen-related cell adhesion molecule 1. A cell-cell adhesion molecule that directly associates with annexin II. Has tumor suppressor activity in prostate carcinoma. Belongs to the immunoglobulin superfamily and the CEA family. Abundantly expressed in epithelia, vessel endothelia, trophoblasts, platelets and neutrophilic granulocytes. Also present in many cell types of the immune system such as B cells, T cells, NK cells, macrophages and dendritic cells. Five alternatively spliced isoforms have been described. Two isoforms are type I membrane proteins, while three are secreted.

Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: adherens junction; apical plasma membrane; basal plasma membrane; brush border membrane; cell junction; cell surface; external side of plasma membrane; extracellular exosome; extracellular space; integral component of membrane; integral component of plasma membrane; intercellular junction; lateral plasma membrane; membrane; microvillus membrane; plasma membrane; T cell receptor complex; transport vesicle

Molecular Function: actin binding; bile acid transmembrane transporter activity; calmodulin binding; filamin binding; granulocyte colony-stimulating factor receptor binding; kinase binding; protein binding; protein dimerization activity; protein homodimerization activity; protein kinase binding; protein phosphatase binding; viral receptor activity; virion binding

Biological Process: bile acid and bile salt transport; blood vessel development; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; cell adhesion; cell-cell adhesion via plasma-membrane adhesion molecules; cell-cell junction organization; cellular response to insulin stimulus; entry of virus into host cell; granulocyte colony-stimulating factor signaling pathway; homophilic cell adhesion; insulin catabolic process; insulin receptor internalization; negative regulation by host of viral process; negative regulation of bone resorption; negative regulation of cytokine production; negative regulation of cytotoxic T cell degranulation; negative regulation of fatty acid biosynthetic process; negative regulation of granulocyte differentiation; negative regulation of hepatocyte proliferation; negative regulation of interleukin-1 production; negative regulation of interleukin-2 production; negative regulation of JNK cascade; negative regulation of lipid biosynthetic process; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; negative regulation of osteoclast differentiation; negative regulation of platelet aggregation; negative regulation of protein kinase activity; negative regulation of T cell mediated cytotoxicity; negative regulation of T cell proliferation; negative regulation of T cell receptor signaling pathway; negative regulation of vascular permeability; Peyer's patch development; positive regulation by host of viral process; positive regulation of CD4-positive, alpha-beta T cell activation; positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of CD8-positive, alpha-beta T cell activation; positive regulation of immunoglobulin secretion; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of NFAT protein import into nucleus; positive regulation of T cell proliferation; positive regulation of vasculogenesis; regulation of cell growth; regulation of cell migration; regulation of endothelial cell differentiation; regulation of endothelial cell migration; regulation of epidermal growth factor receptor signaling pathway; regulation of ERK1 and ERK2 cascade; regulation of phosphatidylinositol 3-kinase signaling; signal transduction; wound healing, spreading of cells