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Interleukin 18 (IL18BP) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2025653
SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment

MBS2025653 is an antibody targeting IL18BP. Also known as Monoclonal Antibody to Interleukin 18 Binding Protein (IL18BP). Reactive in Homo sapiens (Human). Host: Mouse. More details

$215 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interleukin 18 (IL18BP), Monoclonal Antibody
Full Product Name
Monoclonal Antibody to Interleukin 18 Binding Protein (IL18BP)
Product Gene Name
Clonality
Monoclonal
Isotype
IgG2a Kappa
Clone Number
5-2#
Host
Mouse
Species Reactivity
Homo sapiens (Human)
Form/Format
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Purity/Purification
Protein A + Protein G affinity chromatography
Concentration
1mg/mL (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.

Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: IL18BP Clone #5-2# (MBS2025653)
Immunogen: IL18BP (MBS2009781)
Matching Pairs
Unconjugated Antibody: IL18BP Clone #5-2# (MBS2025653)
APC-CY7 Conjugated Antibody: IL18BP Clone #5-2# (MBS2080451)
OMIM
AF110798 Genomic DNA
3D Structure
ModBase 3D Structure for O95998
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Monoclonal antibody preparation
Traits
Liquid
Immunogen
Recombinant IL18BP (Thr31~Gly194) expressed in E.coli(MBS2009781)
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-IL18BP antibody
Western Blot (WB)
Application Notes for anti-IL18BP antibody
Western blotting: 0.01-2ug/mL
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-IL18BP antibody

Western Blot: Sample: Recombinant IL18BP, Human.
Mouse Anti-IL18BP Monoclonal Antibody – Cat# MBS2025653

Other Notes

Small volumes of anti-IL18BP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IL18BP. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interleukin-18-binding protein isoform a
NCBI Official Synonym Full Names
interleukin 18 binding protein
NCBI Official Symbol
IL18BP
NCBI Official Synonym Symbols
IL18BPa
UniProt Protein Name
Interleukin-18-binding protein
UniProt Synonym Protein Names
Tadekinig-alfa
UniProt Gene Name
IL18BP
UniProt Synonym Gene Names
IL-18BP
NCBI Protein Information
interleukin-18-binding protein

NCBI Summary for IL18BP

The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
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UniProt Comments for IL18BP

IL18BP: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: extracellular region; extracellular space

Molecular Function: interleukin-18 binding; receptor antagonist activity

Biological Process: response to lipopolysaccharide; T-helper 1 type immune response
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL18BP antibody

 Reference Product  PubMed Publications
 IL18 antibody  >17 publications with IL18BP and IL18
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