Cyclin Dependent Kinase 5 (CDK5) Antibody – Mouse Monoclonal

This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

CDK5: a protein kinase of the CDK family. Unlike other members of this family, it is not activated by cyclins but by p35 (CDK5R1) and p39. An important regulator of neuronal positioning during brain development. May also play a role in synaptogenesis and neurotransmission. Substrates include TAU, MAP2, NF-H and -M, Nudel, PDE6, beta-catenin, amphyphysin, dynamin I, synapsin 1, Munc-18, and NMDA receptor 2A. Plays a role in myogenesis, haematopoietic cell differentiation, spermatogenesis, insulin secretion, and lens differentiation. Implicated in the pathology of neurofibrillary tangles and formation of senile plaques, hallmarks of Alzheimer?s disease. Induces tau phosphorylation and aggregation and neurofibrillary tangle deposition and neurodegeneration in in vitro and in vivo animal models. Brain samples from Alzeimer?s pateints show elevated CDK5 activity.

Protein type: CDK family; CDK/CDK5 subfamily; CDK5 subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.1; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: axon; cell junction; cell soma; cyclin-dependent protein kinase 5 activator complex; cytoplasm; cytosol; dendrite; filopodium; growth cone; lamellipodium; membrane; microtubule; neuromuscular junction; nucleoplasm; nucleus; perikaryon; plasma membrane; postsynaptic density; postsynaptic membrane; presynapse

Molecular Function: acetylcholine receptor activator activity; ATP binding; cyclin-dependent protein kinase activity; ephrin receptor binding; ErbB-2 class receptor binding; ErbB-3 class receptor binding; kinase activity; microtubule binding; p53 binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; tau-protein kinase activity

Biological Process: axon extension; behavioral response to cocaine; cell cycle; cell division; cell proliferation; cell-matrix adhesion; cellular response to amyloid-beta; central nervous system neuron development; cerebellar cortex formation; corpus callosum development; cortical actin cytoskeleton organization and biogenesis; dendrite morphogenesis; excitatory postsynaptic potential; hippocampus development; intracellular protein transport; layer formation in cerebral cortex; microtubule cytoskeleton organization; motor axon guidance; negative regulation of axon extension; negative regulation of cell cycle; negative regulation of neuron death; negative regulation of protein export from nucleus; negative regulation of protein ubiquitination; negative regulation of proteolysis; negative regulation of synaptic plasticity; negative regulation of transcription, DNA-dependent; neuron apoptosis; neuron differentiation; neuron migration; neuron projection development; nucleocytoplasmic transport; oligodendrocyte differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of actin cytoskeleton reorganization; positive regulation of calcium ion-dependent exocytosis; positive regulation of neuron apoptotic process; positive regulation of protein binding; positive regulation of protein kinase activity; positive regulation of protein targeting to membrane; positive regulation of receptor activity; protein amino acid phosphorylation; protein autophosphorylation; receptor catabolic process; receptor clustering; regulation of apoptosis; regulation of cell cycle arrest; regulation of cell migration; regulation of macroautophagy; regulation of synaptic plasticity; regulation of synaptic transmission, glutamatergic; response to wounding; rhythmic process; Schwann cell development; sensory perception of pain; serine phosphorylation of STAT protein; skeletal muscle tissue development; synaptic transmission; synaptic transmission, dopaminergic; synaptic transmission, glutamatergic; synaptic vesicle endocytosis; synaptic vesicle exocytosis; synaptogenesis; visual learning

Disease: Lissencephaly 7 With Cerebellar Hypoplasia