FK506 Binding Protein 8 (FKBP8) Antibody – Mouse Monoclonal

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]

FKBP8: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Chaperone; EC 5.2.1.8; Isomerase; Membrane protein, integral; Mitochondrial

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; integral component of endoplasmic reticulum membrane; membrane; mitochondrial membrane; mitochondrion; protein complex

Molecular Function: FK506 binding; identical protein binding; metal ion binding; peptidyl-prolyl cis-trans isomerase activity; protein binding

Biological Process: apoptosis; camera-type eye development; cell fate specification; dorsal/ventral neural tube patterning; multicellular organism growth; negative regulation of apoptosis; negative regulation of protein phosphorylation; positive regulation of BMP signaling pathway; protein peptidyl-prolyl isomerization; smoothened signaling pathway; viral process