Lactoferrin (LTF) Antibody – Rabbit Polyclonal

This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

LTF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Belongs to the transferrin family. 2 isoforms of the human protein are produced by alternative promoter.

Protein type: EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cell surface; cytoplasm; extracellular exosome; extracellular region; extracellular space; nucleus; other organism cell membrane; protein complex; secretory granule; specific granule; tertiary granule lumen

Molecular Function: cysteine-type endopeptidase inhibitor activity; DNA binding; heparin binding; iron ion binding; lipopolysaccharide binding; protein binding; protein serine/threonine kinase activator activity; serine-type endopeptidase activity

Biological Process: antibacterial humoral response; antifungal humoral response; antimicrobial humoral immune response mediated by antimicrobial peptide; antimicrobial humoral response; cellular protein metabolic process; defense response to Gram-negative bacterium; humoral immune response; innate immune response in mucosa; ion transport; iron assimilation by chelation and transport; killing of cells of other organism; membrane disruption in other organism; negative regulation by host of viral process; negative regulation of apoptosis; negative regulation of ATPase activity; negative regulation of cysteine-type endopeptidase activity; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of osteoclast development; negative regulation of single-species biofilm formation in or on host organism; negative regulation of tumor necrosis factor (ligand) superfamily member 11 production; negative regulation of viral genome replication; negative regulation of viral process; neutrophil degranulation; ossification; positive regulation of bone mineralization involved in bone maturation; positive regulation of chondrocyte proliferation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; positive regulation of osteoblast differentiation; positive regulation of osteoblast proliferation; positive regulation of protein serine/threonine kinase activity; positive regulation of toll-like receptor 4 signaling pathway; proteolysis; regulation of cytokine production; regulation of tumor necrosis factor production; retinal homeostasis; transcription, DNA-dependent