X-Ray Repair Cross Complementing 5 (XRCC5) Antibody – Rabbit Polyclonal

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

Ku80: the 80-kilodalton subunit of the Ku complex, also known as ATP-dependant DNA helicase II. A single stranded DNA-dependent ATP-dependent helicase. It functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by p70.

Protein type: DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: cytosol; extracellular region; intracellular ribonucleoprotein complex; membrane; nonhomologous end joining complex; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleolus; nucleoplasm; nucleus; plasma membrane; protein complex; secretory granule lumen

Molecular Function: 5'-deoxyribose-5-phosphate lyase activity; ATP binding; ATP-dependent DNA helicase activity; damaged DNA binding; DNA binding; double-stranded DNA binding; double-stranded telomeric DNA binding; enzyme activator activity; protein binding; protein C-terminus binding; RNA binding; telomeric DNA binding; transcription regulatory region DNA binding; ubiquitin protein ligase binding

Biological Process: activation of innate immune response; brain development; cell proliferation; cellular hyperosmotic salinity response; cellular response to fatty acid; cellular response to gamma radiation; cellular response to X-ray; DNA duplex unwinding; DNA recombination; double-strand break repair; double-strand break repair via nonhomologous end joining; innate immune response; negative regulation of t-circle formation; negative regulation of transcription, DNA-dependent; neutrophil degranulation; positive regulation of catalytic activity; positive regulation of interferon type I production; positive regulation of neurogenesis; positive regulation of protein kinase activity; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; regulation of smooth muscle cell proliferation; regulation of telomere maintenance; response to drug; telomere maintenance; transcription, DNA-dependent