Tumor Necrosis Factor Receptor Superfamily (TNFRSF5) Antibody – Rabbit Polyclonal

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]

CD40: a member of the TNF-receptor superfamily. This receptor for CD40L mediates a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3). HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation. Two alternatively spliced isoforms have been reported. Isoform I is a type I membrane protein; isoform II is secreted.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: cell soma; cell surface; cytoplasm; external side of plasma membrane; extracellular exosome; integral component of plasma membrane; intracellular membrane-bound organelle; plasma membrane

Molecular Function: antigen binding; enzyme binding; protein binding; protein domain specific binding; receptor activity; signal transducer activity; tumor necrosis factor-activated receptor activity; ubiquitin protein ligase binding

Biological Process: B cell proliferation; cellular calcium ion homeostasis; cellular response to interleukin-1; defense response to protozoan; defense response to virus; immune response; immune response-regulating cell surface receptor signaling pathway; inflammatory response; multicellular organism development; platelet activation; positive regulation of angiogenesis; positive regulation of B cell proliferation; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell apoptotic process; positive regulation of GTPase activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-12 production; positive regulation of isotype switching to IgG isotypes; positive regulation of MAP kinase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein kinase C signaling; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of STAT protein; protein complex assembly; protein kinase B signaling; regulation of cell proliferation; regulation of immune response; regulation of immunoglobulin secretion; response to cobalamin; response to lipopolysaccharide; response to peptide; tumor necrosis factor-mediated signaling pathway

Disease: Immunodeficiency With Hyper-igm, Type 3