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UDP-Glucose Glycoprotein Glucosyltransferase 1 (UGGT1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2025890
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MBS2025890 is an antibody targeting UGGT1. Also known as Polyclonal Antibody to UDP-Glucose Glycoprotein Glucosyltransferase 1 (UGGT1). Reactive in Human, Pig. Host: Rabbit. More details

$215 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
UDP-Glucose Glycoprotein Glucosyltransferase 1 (UGGT1), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to UDP-Glucose Glycoprotein Glucosyltransferase 1 (UGGT1)
Product Gene Name
anti-UGGT1 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Pig
Form/Format
Liquid
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against UGGT1. It has beenselected for its ability to recognize UGGT1 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: UGGT1 (MBS2025890)
Immunogen: UGGT1 (MBS2030426)
Matching Pairs
Unconjugated Antibody: UGGT1 (MBS2025890)
APC-CY7 Conjugated Antibody: UGGT1 (MBS2081032)
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Molecular Weight
174,977 Da
OMIM
AF227905 mRNA
3D Structure
ModBase 3D Structure for Q9NYU2
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Fragment
UGGT1 (Leu1221~Leu1536)
Organism Species
Homo sapiens (Human)
Cross Reactivity
Human, Pig
Conjugate
No Conjugate
Immunogen
Recombinant UGGT1 (Leu1221~Leu1536) expressed in E Coli.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2081034

Product Categories/Family for anti-UGGT1 antibody

Knock-Out Validation Antibody
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-UGGT1 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
Application Notes for anti-UGGT1 antibody
Western blotting: 0.2-2ug/mL;1:250-2500
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-UGGT1 antibody

Western Blot: Sample: Human Jurakt cell lysate; Primary Ab: 3ug/ml Rabbit Anti-Human UGGT1 Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;
Rabbit Anti-UGGT1 Polyclonal Antibody – Cat# MBS2025890

Western Blot (WB) of anti-UGGT1 antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-UGGT1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS2025890

Immunohistochemistry (IHC) of anti-UGGT1 antibody

DAB staining on IHC-P. Samples: Human Tissue)
Rabbit Anti-UGGT1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2025890

Knockout Validation of anti-UGGT1 antibody

Knockout Validation: Lane 1: Wild-type Jurkat cell lysate; Lane 2: UGGT1 knockout Jurkat cell lysate; Predicted MW: 170kd Observed MW: 170kd Primary Ab: 3ug/ml Rabbit Anti-Human UGGT1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047)
Rabbit Anti-UGGT1 Polyclonal Antibody, Knockout Validation – Cat# MBS2025890

Other Notes

Small volumes of anti-UGGT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for UGGT1. It may not necessarily be applicable to this product.

NCBI GI #
9910280
NCBI GeneID
56886
NCBI Accession #
NP_064505.1
UniProt Primary Accession #
Q9NYU2
UniProt Secondary Accession #
Q53QP2; Q53SL3; Q8IW30; Q9H8I4
UniProt Related Accession #
Q9NYU2
GenBank Nucleotide #
NM_020120.3
NCBI Official Full Name
UDP-glucose:glycoprotein glucosyltransferase 1
NCBI Official Synonym Full Names
UDP-glucose glycoprotein glucosyltransferase 1
NCBI Official Symbol
UGGT1
NCBI Official Synonym Symbols
UGT1; HUGT1; UGCGL1
UniProt Protein Name
UDP-glucose:glycoprotein glucosyltransferase 1
UniProt Synonym Protein Names
UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1
Protein Family
UDP-glucose:glycoprotein glucosyltransferase
UniProt Gene Name
UGGT1
UniProt Synonym Gene Names
; UGT1; hUGT1
NCBI Protein Information
UDP-glucose:glycoprotein glucosyltransferase 1

NCBI Summary for UGGT1

UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]

UniProt Comments for UGGT1

UGCGL1: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Belongs to the glycosyltransferase 8 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.4.1.-; Transferase

Chromosomal Location of Human Ortholog: 2q14.3

Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment; protein complex

Molecular Function: protein binding; UDP-glucose:glycoprotein glucosyltransferase activity; unfolded protein binding

Biological Process: de novo'posttranslational protein folding; endoplasmic reticulum unfolded protein response; protein N-linked glycosylation via asparagine
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Research Articles on UGGT1

1. both vIL-6 and VKORC1v2 interact with calnexin cycle proteins UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1), which catalyzes monoglucosylation of N-glycans, and oppositely acting glucosidase II (GlucII), and that vIL-6 can promote protein folding.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UGGT1 antibody

 Reference Product  PubMed Publications
 SEP15 antibody  >2 publications with UGGT1 and SEP15

Pathways associated with anti-UGGT1 antibody

 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Calnexin/calreticulin Cycle Pathway antibodies  Calnexin/calreticulin Cycle Pathway Diagram
 ER Quality Control Compartment (ERQC) Pathway antibodies  ER Quality Control Compartment (ERQC) Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 N-glycan Trimming In The ER And Calnexin/Calreticulin Cycle Pathway antibodies  N-glycan Trimming In The ER And Calnexin/Calreticulin Cycle Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with anti-UGGT1 antibody

 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >1 publications with UGGT1 and Lung Diseases
 Inflammation Antibodies  >1 publications with UGGT1 and Inflammation
 Liver Diseases Antibodies  >1 publications with UGGT1 and Liver Diseases

Organs/Tissues associated with anti-UGGT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >1 publications with UGGT1 and Pancreas
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