Cadherin EGF LAG Seven Pass G-Type Receptor 3 (CELSR3) Antibody – Rabbit Polyclonal

This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]

CELSR3: Receptor that may have an important role in cell/cell signaling during nervous system formation. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: integral component of membrane; plasma membrane

Molecular Function: calcium ion binding; G-protein coupled receptor activity; protein binding

Biological Process: axonal fasciculation; dopaminergic neuron axon guidance; G-protein coupled receptor signaling pathway; homophilic cell adhesion; neuron migration; planar cell polarity pathway involved in axon guidance; regulation of protein amino acid phosphorylation; regulation of protein localization; serotonergic neuron axon guidance; Wnt receptor signaling pathway, planar cell polarity pathway