Nuclear Receptor Coactivator 3 (NCOA3) Antibody – Rabbit Polyclonal

SRC-3: a histone acetyltransferase and nuclear receptor coactivator. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Activity is enhanced by various hormones and TNF. Acetylation by CREBBP may suppress coactivation of target genes by disrupting its association with nuclear receptors. Frequently amplified or overexpressed in breast and ovarian cancers. Five alternatively spliced isoforms have been described.

Protein type: Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 3q42

Cellular Component: cytoplasm; cytosol; Golgi apparatus; nuclear chromatin; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein complex

Molecular Function: androgen receptor binding; chromatin binding; estrogen receptor binding; histone acetyltransferase activity; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; peroxisome proliferator activated receptor binding; protein complex binding; protein heterodimerization activity; protein N-terminus binding; transcription coactivator activity

Biological Process: cell dedifferentiation; developmental growth; histone acetylation; male gonad development; multicellular organism growth; negative regulation of apoptosis; positive regulation of cell growth; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of keratinocyte differentiation; positive regulation of steroid hormone receptor signaling pathway; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; vagina development