Atpase (ATP5b) Antibody – Rabbit Polyclonal

ATP5B: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Belongs to the ATPase alpha/beta chains family.

Protein type: EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Mitochondrial

Chromosomal Location of Human Ortholog: 7q11

Cellular Component: cell surface; extracellular matrix; membrane; membrane raft; mitochondrial inner membrane; mitochondrial membrane; mitochondrial proton-transporting ATP synthase complex; mitochondrion; myelin sheath; nucleus; plasma membrane; proton-transporting ATP synthase complex; proton-transporting ATP synthase complex, catalytic core F(1)

Molecular Function: angiostatin binding; ATP binding; ATPase activity; calcium ion binding; hydrogen ion transporting ATPase activity, rotational mechanism; lipoprotein receptor activity; MHC class I protein binding; proton-transporting ATP synthase activity, rotational mechanism

Biological Process: angiogenesis; ATP biosynthetic process; ATP metabolic process; ATP synthesis coupled proton transport; lipid metabolic process; negative regulation of cell adhesion involved in substrate-bound cell migration; osteoblast differentiation; positive regulation of blood vessel endothelial cell migration; proton transport; receptor-mediated endocytosis; regulation of intracellular pH