Cyclic AMP Response Element (CREB) Antibody – Rabbit Polyclonal

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

CREB: a transcription factor of the leucine zipper family of DNA binding proteins. Binds as a homodimer to the cAMP-responsive element (CRE). Phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Two splice-variant isoforms have been described.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2q33.3

Cellular Component: ATF4-CREB1 transcription factor complex; axon; mitochondrial matrix; nuclear euchromatin; nucleoplasm; nucleus

Molecular Function: DNA binding transcription factor activity; enzyme binding; histone acetyltransferase binding; Hsp70 protein binding; identical protein binding; protein binding; transcription cofactor activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

Biological Process: aging; axon guidance; cellular response to fatty acid; cellular response to insulin-like growth factor stimulus; cellular response to zinc ion; chemotaxis to arachidonic acid; circadian rhythm; lactation; memory; negative regulation of neuron death; negative regulation of transcription by competitive promoter binding; pituitary gland development; positive regulation of apoptosis; positive regulation of cardiac muscle tissue development; positive regulation of fat cell differentiation; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; positive regulation of long-term synaptic potentiation; positive regulation of multicellular organism growth; positive regulation of osteoclast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; positive regulation of transcriptional preinitiation complex assembly; positive regulation of transforming growth factor beta3 production; protein amino acid phosphorylation; protein kinase B signaling; protein stabilization; regulation of cell size; regulation of circadian rhythm; regulation of fibroblast proliferation; response to activity; response to drug; response to glucagon; response to hypoxia; response to L-glutamate; response to nicotine; response to organic substance; secretory granule organization and biogenesis; signal transduction; transcription from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; viral process; visual learning

Disease: Histiocytoma, Angiomatoid Fibrous