Syntenin 1 (ST1) Antibody – Rabbit Polyclonal

The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Jan 2017]

syntenin: Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Cell adhesion; Cytokine; Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle

Chromosomal Location of Human Ortholog: 8q12.1

Cellular Component: adherens junction; blood microparticle; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum membrane; extracellular exosome; extracellular region; extracellular space; focal adhesion; interleukin-5 receptor complex; intracellular membrane-bound organelle; melanosome; membrane; membrane raft; nuclear membrane; nucleoplasm; nucleus; plasma membrane

Molecular Function: cadherin binding; cytoskeletal adaptor activity; frizzled binding; identical protein binding; interleukin-5 receptor binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein heterodimerization activity; protein N-terminus binding; syndecan binding

Biological Process: actin cytoskeleton organization; ephrin receptor signaling pathway; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of receptor internalization; neutrophil degranulation; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of JNK cascade; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; protein targeting to membrane; regulation of mitotic cell cycle; substrate-dependent cell migration, cell extension; synaptic transmission