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Glucokinase Regulatory Protein (GKRP) Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2026570
SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment

MBS2026570 is an antibody targeting GKRP. Also known as Polyclonal Antibody to Glucokinase Regulatory Protein (GKRP). Reactive in Rat, Human, Mouse. Host: Mouse. More details

$215 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Glucokinase Regulatory Protein (GKRP), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Glucokinase Regulatory Protein (GKRP)
Product Gene Name
anti-GKRP antibody
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-V GISLEKKGRV HLVGWQTLGI IAIMDGVECI HTFGADFQDI RGFLIGDHSD MFNQKDELTN QGPQFTFSQD DFLTSILPSL TETDTVVFIF TLDDNLTEVQ ALAERVREKC QNIQALVHST VGQSLPAPLK KLFPSLISIT WPLLFFDYEG TYVQKFQREL
Clonality
Polyclonal
Host
Mouse
Species Reactivity
Rat, Human, Mouse
Form/Format
Liquid
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against GKRP. It has beenselected for its ability to recognize GKRP in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: GKRP (MBS2026570)
Immunogen: GKRP (MBS2031091)
Matching Pairs
Unconjugated Antibody: GKRP (MBS2026570)
Cy3 Conjugated Antibody: GKRP (MBS2054359)
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Molecular Weight
68,917 Da
3D Structure
ModBase 3D Structure for Q07071
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Fragment
GKRP (Val320~Lys499)
Organism Species
Rattus norvegicus (Rat)
Cross Reactivity
Rat
Conjugate
No Conjugate
Immunogen
Recombinant GKRP (Val320~Lys499) expressed in E Coli.
Conjugated Antibody
The Cy3 conjugated antibody version of this item is also available as catalog #MBS2054359
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-GKRP antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
Application Notes for anti-GKRP antibody
Western blotting: 0.2-2ug/mL;1:250-2500
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-GKRP antibody

Western Blot: Sample: Recombinant protein.
Mouse Anti-GKRP Polyclonal Antibody – Cat# MBS2026570

Immunohistochemistry (IHC) of anti-GKRP antibody

DABstainingonIHC-P.Samples:RatTissue)
Mouse Anti-GKRP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2026570

Other Notes

Small volumes of anti-GKRP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GKRP. It may not necessarily be applicable to this product.

NCBI GI #
6978884
NCBI GeneID
25658
NCBI Accession #
NP_037252.1
UniProt Primary Accession #
Q07071
UniProt Related Accession #
Q07071
GenBank Nucleotide #
NM_013120.2
NCBI Official Full Name
glucokinase regulatory protein
NCBI Official Synonym Full Names
glucokinase regulator
NCBI Official Symbol
Gckr
NCBI Official Synonym Symbols
GLRE
UniProt Protein Name
Glucokinase regulatory protein
Protein Family
Glucokinase regulatory protein
UniProt Gene Name
Gckr
UniProt Synonym Gene Names
Glucokinase regulator
NCBI Protein Information
glucokinase regulatory protein

NCBI Summary for GKRP

inhibits the activity of glucokinase; plays a role in glucose metabolism and homeostasis [RGD, Feb 2006]

UniProt Comments for GKRP

GCKR: a key regulator of glucokinase in the liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen. When expressed alone, both glucokinase and GCKR localize predominantly to the cytoplasm. Co-expression induces both proteins to localize in the nucleus.

Protein type: Inhibitor; Mitochondrial

Chromosomal Location of Human Ortholog: 6q14

Cellular Component: cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus

Molecular Function: carbohydrate binding; enzyme binding; enzyme inhibitor activity; protein binding; protein domain specific binding

Biological Process: cell glucose homeostasis; detection of glucose; glucose metabolic process; negative regulation of glucokinase activity; positive regulation of glucokinase activity; protein import into nucleus, translocation; response to fructose stimulus; urate metabolic process
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Research Articles on GKRP

1. When GK is pre-incubated with glucose and compound A, the inhibition observed by GKRP is time dependent, but independent of GKRP concentration, reflecting the GKA-controlled transition between closed and open GK conformations.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-GKRP antibody

 Disease Name  Pubmed Publications
 Diabetes Mellitus, Type 2 Antibodies  >38 publications with GKRP and Diabetes Mellitus, Type 2
 Cardiovascular Diseases Antibodies  >19 publications with GKRP and Cardiovascular Diseases
 Hyperglycemia Antibodies  >14 publications with GKRP and Hyperglycemia
 Liver Diseases Antibodies  >12 publications with GKRP and Liver Diseases
 Heart Diseases Antibodies  >12 publications with GKRP and Heart Diseases
 Hypertriglyceridemia Antibodies  >11 publications with GKRP and Hypertriglyceridemia
 Hyperlipidemias Antibodies  >10 publications with GKRP and Hyperlipidemias
 Fatty Liver Antibodies  >8 publications with GKRP and Fatty Liver
 Kidney Diseases Antibodies  >7 publications with GKRP and Kidney Diseases
 Necrosis Antibodies  >6 publications with GKRP and Necrosis

Organs/Tissues associated with anti-GKRP antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >54 publications with GKRP and Liver
 Heart Antibodies  >17 publications with GKRP and Heart
 Pancreas Antibodies  >15 publications with GKRP and Pancreas
 Brain Antibodies  >7 publications with GKRP and Brain
 Lung Antibodies  >1 publications with GKRP and Lung
 Connective Tissue Antibodies  >1 publications with GKRP and Connective Tissue
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