Major Vault Protein (MVP) Antibody – Rabbit Polyclonal

This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

MVP: Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoplasm; cytoskeleton; cytosol; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; intracellular ribonucleoprotein complex; membrane; nuclear pore; nucleus; perinuclear region of cytoplasm; secretory granule lumen

Molecular Function: identical protein binding; protein binding; protein kinase binding; protein phosphatase binding

Biological Process: ERBB signaling pathway; mRNA transport; negative regulation of protein autophosphorylation; neutrophil degranulation; protein transport