Cytochrome P450 21b (CYP21B) Antibody – Rabbit Polyclonal

CYP21A2: Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. Defects in CYP21A2 are the cause of adrenal hyperplasia type 3 (AH3). AH3 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: 'salt wasting' (SW, the most severe type), 'simple virilizing' (SV, less severely affected patients), with normal aldosterone biosynthesis, 'non-classic form' or late onset (NC or LOAH), and 'cryptic' (asymptomatic). Belongs to the cytochrome P450 family.

Protein type: EC 1.14.99.10; Lipid Metabolism - C21-steroid hormone; Oxidoreductase

Chromosomal Location of Human Ortholog: 17 B1|17 18.36 cM

Cellular Component: endoplasmic reticulum; intracellular membrane-bound organelle; membrane

Molecular Function: heme binding; iron ion binding; lipid binding; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; steroid 21-monooxygenase activity; steroid binding; steroid hydroxylase activity

Biological Process: C21-steroid hormone biosynthetic process; mineralocorticoid biosynthetic process; progesterone metabolic process; steroid biosynthetic process; steroid metabolic process