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Ficolin 2 (FCN2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2028168
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MBS2028168 is an antibody targeting FCN2. Also known as Polyclonal Antibody to Ficolin 2 (FCN2). Reactive in Mouse. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Ficolin 2 (FCN2), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Ficolin 2 (FCN2)
Product Gene Name
anti-FCN2 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
0.5mg/mL (lot specific)
Matching Pairs
Unconjugated Antibody: FCN2 (MBS2028168)
Immunogen: FCN2 (MBS2029895)
Matching Pairs
Unconjugated Antibody: FCN2 (MBS2028168)
APC-CY7 Conjugated Antibody: FCN2 (MBS2060462)
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3D Structure
ModBase 3D Structure for O70497
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Polyclonal antibody preparation
Traits
Liquid
Immunogen
Recombinant FCN2 (Gln97~Ser254) expressed in E.coli (MBS2029895).
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-FCN2 antibody
Western Blot (WB); Immunohistochemistry (IHC); Immunocytochemistry (ICC); Immunoprecipitation (IP).
Application Notes for anti-FCN2 antibody
Western blotting: 0.01-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-FCN2 antibody

Western Blot:
Sample: Recombinant FCN2, Mouse.
Rabbit Anti-FCN2 Polyclonal Antibody – Cat# MBS2028168

Immunohistochemistry (IHC) of anti-FCN2 antibody

DAB staining on fromalin fixed paraffin-embedded Liver tissue
Rabbit Anti-FCN2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2028168

Other Notes

Small volumes of anti-FCN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FCN2. It may not necessarily be applicable to this product.

NCBI GI #
77404440
NCBI GeneID
14134
NCBI Accession #
NP_034320.1
UniProt Primary Accession #
O70497
UniProt Secondary Accession #
Q3KNL6
UniProt Related Accession #
O70497
GenBank Nucleotide #
NM_010190.1
NCBI Official Full Name
ficolin-2
NCBI Official Synonym Full Names
ficolin B
NCBI Official Symbol
Fcnb
NCBI Official Synonym Symbols
Fcn2
UniProt Protein Name
Ficolin-2
UniProt Synonym Protein Names
Collagen/fibrinogen domain-containing protein 2; Ficolin-B; Ficolin-beta; L-ficolin
Protein Family
Ficolin
UniProt Gene Name
Fcn2
UniProt Synonym Gene Names
Fcnb
NCBI Protein Information
ficolin-2

UniProt Comments for FCN2

FCN2: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region. Belongs to the ficolin lectin family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 2|2 A3

Cellular Component: collagen; extracellular region; extrinsic to external side of plasma membrane

Molecular Function: carbohydrate binding; G-protein coupled receptor binding; metal ion binding; sialic acid binding; signaling pattern recognition receptor activity

Biological Process: cell surface pattern recognition receptor signaling pathway; complement activation, lectin pathway; G-protein coupled receptor signaling pathway; immune system process; innate immune response; negative regulation of virion penetration into host cell; recognition of apoptotic cell
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Research Articles on FCN2

1. this study demonstrates that ficolins are important in initial innate host defense against Aspergillus fumigatus infections in vivo

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-FCN2 antibody

 Products by Pathway  Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Creation Of C4 And C2 Activators Pathway antibodies  Creation Of C4 And C2 Activators Pathway Diagram
 Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway antibodies  Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Initial Triggering Of Complement Pathway antibodies  Initial Triggering Of Complement Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Lectin Pathway Of Complement Activation antibodies  Lectin Pathway Of Complement Activation Diagram

Diseases associated with anti-FCN2 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >2 publications with FCN2 and Necrosis
 Lung Diseases Antibodies  >1 publications with FCN2 and Lung Diseases
 Autoimmune Diseases Antibodies  >1 publications with FCN2 and Autoimmune Diseases
 Immune System Diseases Antibodies  >1 publications with FCN2 and Immune System Diseases

Organs/Tissues associated with anti-FCN2 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >1 publications with FCN2 and Bone Marrow
 Liver Antibodies  >1 publications with FCN2 and Liver
 Spleen Antibodies  >1 publications with FCN2 and Spleen
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