Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Antibody – Rabbit Polyclonal

PTPRJ: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling. Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine

Chromosomal Location of Human Ortholog: 2 E1|2 50.19 cM

Cellular Component: cell junction; cell projection; cell surface; extracellular exosome; immunological synapse; integral component of membrane; intercellular junction; membrane; plasma membrane

Molecular Function: beta-catenin binding; delta-catenin binding; gamma-catenin binding; hydrolase activity; mitogen-activated protein kinase binding; phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity; platelet-derived growth factor receptor binding; protein kinase binding; protein tyrosine phosphatase activity

Biological Process: blood coagulation; dephosphorylation; heart development; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein kinase B signaling cascade; negative regulation of receptor activity; negative regulation of T cell receptor signaling pathway; negative regulation of vascular permeability; oligodendrocyte differentiation; platelet-derived growth factor receptor signaling pathway; positive chemotaxis; positive regulation of cell adhesion; positive regulation of cell-matrix adhesion; positive regulation of focal adhesion assembly; positive regulation of macrophage chemotaxis; positive regulation of platelet activation; positive regulation of protein kinase B signaling; protein amino acid dephosphorylation; regulation of cell adhesion; vasculogenesis