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Lymphocyte Function Associated Antigen 3 (LFA3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2028295
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MBS2028295 is an antibody targeting LFA3. Also known as Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3). Reactive in Human. Host: Rabbit. More details

$205 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Lymphocyte Function Associated Antigen 3 (LFA3), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Lymphocyte Function Associated Antigen 3 (LFA3)
Product Gene Name
anti-LFA3 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Affinity Chromatography
Concentration
0.77mg/ml (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against LFA3. It has beenselected for its ability to recognize LFA3 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: LFA3 (MBS2028295)
Immunogen: LFA3 (MBS2028904)
Matching Pairs
Unconjugated Antibody: LFA3 (MBS2028295)
APC-CY7 Conjugated Antibody: LFA3 (MBS2049400)
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Molecular Weight
27,960 Da
OMIM
Y00636 mRNA
3D Structure
ModBase 3D Structure for P19256
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Fragment
LFA3 (Met1~His214)
Organism Species
Homo sapiens (Human)
Cross Reactivity
Human
Conjugate
No Conjugate
Immunogen
Recombinant LFA3 (Met1~His214) expressed in E Coli.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2049402
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-LFA3 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
Application Notes for anti-LFA3 antibody
Western blotting: 0.2-2ug/mL;1:250-2500
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-LFA3 antibody

Western Blot: Sample: Human K562 cell lysate; Primary Ab: 1ug/ml Rabbit Anti-Human LFA3 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
Rabbit Anti-LFA3 Polyclonal Antibody – Cat# MBS2028295

Western Blot (WB) of anti-LFA3 antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-LFA3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS2028295

Immunohistochemistry (IHC) of anti-LFA3 antibody

DAB staining on IHC-P. Samples: Human Tissue)
Rabbit Anti-LFA3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2028295

Other Notes

Small volumes of anti-LFA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LFA3. It may not necessarily be applicable to this product.

NCBI GI #
221316575
NCBI GeneID
965
NCBI Accession #
NP_001138294.1
UniProt Primary Accession #
P19256
UniProt Secondary Accession #
Q5U053; Q6IB65; Q96KI9; A8K7G5
UniProt Related Accession #
P19256
GenBank Nucleotide #
NM_001144822.1
NCBI Official Full Name
lymphocyte function-associated antigen 3 isoform 2
NCBI Official Synonym Full Names
CD58 molecule
NCBI Official Symbol
CD58
NCBI Official Synonym Symbols
ag3; LFA3; LFA-3
UniProt Protein Name
Lymphocyte function-associated antigen 3
UniProt Synonym Protein Names
Surface glycoprotein LFA-3; CD_antigen: CD58
Protein Family
Lymphocyte function-associated antigen
UniProt Gene Name
CD58
UniProt Synonym Gene Names
LFA3; Ag3
NCBI Protein Information
lymphocyte function-associated antigen 3

NCBI Summary for LFA3

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
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UniProt Comments for LFA3

CD58: Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen- presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, GPI anchor; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: cell surface; integral component of plasma membrane; membrane; plasma membrane; secretory granule membrane

Molecular Function: protein binding; receptor binding

Biological Process: cell adhesion; heterotypic cell-cell adhesion; leukocyte migration; neutrophil degranulation
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Research Articles on LFA3

1. A new neuromyelitis optica spectrum disorders susceptibility variant was identified, rs56302466, on the CD58 gene, in a Han Chinese population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LFA3 antibody

 Reference Product  PubMed Publications
 CD2 antibody  >414 publications with LFA3 and CD2
 DNAJA1 antibody  >1 publications with LFA3 and DNAJA1

Pathways associated with anti-LFA3 antibody

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram

Diseases associated with anti-LFA3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >262 publications with LFA3 and Neoplasms
 Necrosis Antibodies  >108 publications with LFA3 and Necrosis
 Leukemia Antibodies  >100 publications with LFA3 and Leukemia
 Autoimmune Diseases Antibodies  >59 publications with LFA3 and Autoimmune Diseases
 Inflammation Antibodies  >41 publications with LFA3 and Inflammation
 Neoplasms, Experimental Antibodies  >40 publications with LFA3 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >36 publications with LFA3 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >27 publications with LFA3 and Cardiovascular Diseases
 Anemia Antibodies  >22 publications with LFA3 and Anemia
 Liver Diseases Antibodies  >22 publications with LFA3 and Liver Diseases

Organs/Tissues associated with anti-LFA3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >738 publications with LFA3 and Blood
 Bone Antibodies  >83 publications with LFA3 and Bone
 Bone Marrow Antibodies  >80 publications with LFA3 and Bone Marrow
 Skin Antibodies  >40 publications with LFA3 and Skin
 Lung Antibodies  >33 publications with LFA3 and Lung
 Liver Antibodies  >30 publications with LFA3 and Liver
 Brain Antibodies  >23 publications with LFA3 and Brain
 Embryonic Tissue Antibodies  >18 publications with LFA3 and Embryonic Tissue
 Lymph Node Antibodies  >17 publications with LFA3 and Lymph Node
 Kidney Antibodies  >17 publications with LFA3 and Kidney
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