Serine/Threonine Kinase 39 (STK39) Antibody – Rabbit Polyclonal

This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]

STLK3: May act as a mediator of stress-activated signals. The phosphorylated form forms a complex with WNK2. Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

Protein type: EC 2.7.11.1; FRAY subfamily; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family

Chromosomal Location of Human Ortholog: 2q24.3

Cellular Component: apical plasma membrane; basolateral plasma membrane; cytoplasm; cytoskeleton; cytosol; extrinsic component of membrane; intracellular membrane-bound organelle; nucleoplasm; nucleus

Molecular Function: ATP binding; kinase activity; protein binding; protein kinase binding; protein serine/threonine kinase activity; signal transducer, downstream of receptor, with serine/threonine kinase activity

Biological Process: activation of protein kinase activity; cellular hypotonic response; maintenance of lens transparency; negative regulation of creatine transmembrane transporter activity; negative regulation of pancreatic juice secretion; negative regulation of potassium ion transmembrane transport; negative regulation of potassium ion transmembrane transporter activity; negative regulation of protein phosphorylation; negative regulation of rubidium ion transmembrane transporter activity; negative regulation of rubidium ion transport; negative regulation of sodium ion transmembrane transporter activity; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of ion transmembrane transporter activity; positive regulation of potassium ion transport; protein amino acid phosphorylation; protein autophosphorylation; regulation of apoptosis; regulation of blood pressure; regulation of inflammatory response; regulation of ion homeostasis; regulation of mitotic cell cycle; response to stress; stress-activated protein kinase signaling pathway