Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a) Antibody – Rabbit Polyclonal

ENaC-alpha: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Probable heterotrimer containing one alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. By aldosterone. Highly expressed in kidney and lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart. Activated by WNK1, WNK2, WNK3 and WNK4. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel

Chromosomal Location of Human Ortholog: 6 F3|6 59.32 cM

Cellular Component: apical plasma membrane; cell projection; cortical actin cytoskeleton; cytoplasm; cytosol; external side of plasma membrane; extracellular exosome; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; sodium channel complex

Molecular Function: actin binding; ligand-gated sodium channel activity; sodium channel activity; WW domain binding

Biological Process: ion transport; multicellular organismal water homeostasis; regulation of body fluid levels; response to stimulus; sensory perception of taste; sodium ion homeostasis; sodium ion transport; transport