VAMP2 Recombinant Protein – Cat# MBS203017

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

Synaptobrevin 2 (VAMP2) Recombinant Protein

Name: VAMP2 Recombinant Protein; Synaptobrevin 2; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203017
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203017

Synaptobrevin 2 (Vehicle-associated membrane, VAMP2), which is an 18 kDa integral membrane protein localized to the cytoplasmic surface of synaptic vesicle, consists of a proline-rich N-terminal region, a highly conserved hydrophilic domain, followed by a… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Synaptobrevin 2 (VAMP2), Recombinant Protein

Full Product Name

Synaptobrevin 2,1-89aa, Human, His tag, E Coli

Product Gene Name

VAMP2 recombinant protein

Product Synonym Names

vesicle-associated membrane protein 2; VAMP2; SYB2; Synaptobrevin 2; VAMP-2; Synaptobrevin-2; Vesicle-associated membrane protein 2; vesicle-associated membrane protein 2 FLJ11460; RATVAMPB; RATVAMPIR; SYB; VAMP 2; Vesicle associated membrane protein 2; Vesicle-associated membrane protein 2 (synaptobrevin 2).

Sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMSA TAATAPPAAP AGEGGPPAPP PNLTSNRRLQ QTQAQVDEVV DIMRVNVDKV LERDQKLSEL DDRADALQAG ASQFETSAAK LKRKYW

Host

E Coli

Form/Format

Liquid. In phosphate-buffered saline (pH 7.4), 1mM EDTA

Purity/Purification

> 95% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 2°C to 8°C for 1 week.
For long term storage, aliquot and store at -20°C to -80°C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

13.8 kDa (126 aa)

3D Structure

ModBase 3D Structure for P63027

Tag Information

His-tag

Domain

1-89aa

Product Categories/Family for VAMP2 recombinant protein

Neuroscience

Applications Tested/Suitable for VAMP2 recombinant protein

SDS-PAGE

Product References and Citations for VAMP2 recombinant protein

Lin RC. and Scheller RH. (1997) Neuron. 19:1087-1094.; Hanson PI. et al (1997) Cell 90:523-535.; Scales SJ., et al. (2002) J Biol Chem. 277 (31):28271-9.; Windoffer R et al. (1999) Cell Tissue Res 296:499-510;

Other Notes

Small volumes of VAMP2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VAMP2 purchase

MBS203017 is a recombinant protein targeting VAMP2. Also known as Synaptobrevin 2,1-89aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for VAMP2. It may not necessarily be applicable to this product.

NCBI GI #

172072620

NCBI GeneID

6844

NCBI Accession #

NP_055047

UniProt Primary Accession #

P63027

UniProt Secondary Accession #

P19065; Q9BUC2

UniProt Related Accession #

P63027

GenBank Nucleotide #

NM_014232.2

NCBI Official Full Name

vesicle-associated membrane protein 2 isoform 1

NCBI Official Synonym Full Names

vesicle associated membrane protein 2

NCBI Official Symbol

VAMP2

NCBI Official Synonym Symbols

SYB2; VAMP-2

UniProt Protein Name

Vesicle-associated membrane protein 2

UniProt Synonym Protein Names

Synaptobrevin-2

Protein Family

Vesicle-associated membrane protein

UniProt Gene Name

VAMP2

UniProt Synonym Gene Names

SYB2; VAMP-2

NCBI Protein Information

vesicle-associated membrane protein 2

NCBI Summary for VAMP2

The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]

UniProt Comments for VAMP2

Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.

Research Articles on VAMP2

1. Data suggest that A-syn (alpha-synuclein) promotes SNARE-dependent vesicle docking; phosphatidylserine (PS) removal from t-SNARE-bearing vesicles causes A-syn to inhibit vesicle docking; PS removal from v-SNARE-bearing vesicles promotes vesicle docking; the C-terminal 45 residues of A-syn are required for promotion of vesicle docking. (Here, t-SNARE is SNAP-25; v-SNARE is VAMP2.)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with VAMP2 recombinant protein

Reference Product	PubMed Publications
SNAP25 recombinant protein	>115 publications with VAMP2 and SNAP25
SNAP23 recombinant protein	>53 publications with VAMP2 and SNAP23
STX1A recombinant protein	>40 publications with VAMP2 and STX1A
SYT1 recombinant protein	>25 publications with VAMP2 and SYT1
STXBP1 recombinant protein	>11 publications with VAMP2 and STXBP1
STX4 recombinant protein	>4 publications with VAMP2 and STX4
SNAP29 recombinant protein	>1 publications with VAMP2 and SNAP29
STX3 recombinant protein	>1 publications with VAMP2 and STX3
NAPA recombinant protein	>1 publications with VAMP2 and NAPA
STX6 recombinant protein	>1 publications with VAMP2 and STX6

Pathways associated with VAMP2 recombinant protein

Products by Pathway	Pathway Diagram
Acetylcholine Neurotransmitter Release Cycle Pathway antibodies	Acetylcholine Neurotransmitter Release Cycle Pathway Diagram
Cargo Recognition For Clathrin-mediated Endocytosis Pathway antibodies	Cargo Recognition For Clathrin-mediated Endocytosis Pathway Diagram
Clathrin Derived Vesicle Budding Pathway antibodies	Clathrin Derived Vesicle Budding Pathway Diagram
Clathrin-mediated Endocytosis Pathway antibodies	Clathrin-mediated Endocytosis Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Dopamine Neurotransmitter Release Cycle Pathway antibodies	Dopamine Neurotransmitter Release Cycle Pathway Diagram
Effects Of Botulinum Toxin Pathway antibodies	Effects Of Botulinum Toxin Pathway Diagram
GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies	GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
Glutamate Neurotransmitter Release Cycle Pathway antibodies	Glutamate Neurotransmitter Release Cycle Pathway Diagram
Golgi Associated Vesicle Biogenesis Pathway antibodies	Golgi Associated Vesicle Biogenesis Pathway Diagram

Diseases associated with VAMP2 recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>57 publications with VAMP2 and Nervous System Diseases
Disease Models, Animal Antibodies	>32 publications with VAMP2 and Disease Models, Animal
Inflammation Antibodies	>12 publications with VAMP2 and Inflammation
Seizures Antibodies	>10 publications with VAMP2 and Seizures
Cognition Disorders Antibodies	>9 publications with VAMP2 and Cognition Disorders
Depressive Disorder Antibodies	>7 publications with VAMP2 and Depressive Disorder
Cardiovascular Diseases Antibodies	>6 publications with VAMP2 and Cardiovascular Diseases
Memory Disorders Antibodies	>6 publications with VAMP2 and Memory Disorders
Movement Disorders Antibodies	>6 publications with VAMP2 and Movement Disorders
Neurobehavioral Manifestations Antibodies	>6 publications with VAMP2 and Neurobehavioral Manifestations

Organs/Tissues associated with VAMP2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>257 publications with VAMP2 and Brain
Nerve Antibodies	>189 publications with VAMP2 and Nerve
Muscle Antibodies	>89 publications with VAMP2 and Muscle
Blood Antibodies	>46 publications with VAMP2 and Blood
Pancreas Antibodies	>45 publications with VAMP2 and Pancreas
Kidney Antibodies	>29 publications with VAMP2 and Kidney
Eye Antibodies	>22 publications with VAMP2 and Eye
Heart Antibodies	>16 publications with VAMP2 and Heart
Embryonic Tissue Antibodies	>16 publications with VAMP2 and Embryonic Tissue
Lung Antibodies	>15 publications with VAMP2 and Lung