AHA1 Recombinant Protein – Cat# MBS203038

Activator of Hsp90 Atpase-1 (AHA1) Recombinant Protein

Name: AHA1 Recombinant Protein; MyBioSource
Brand: MyBioSource
SKU: MBS203038
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203038

The co-chaperone Aha1 (Activator of HSP90 ATPase-1) binds the middle domain of Hsp90 (amino acid 272-627) and is proposed to function as an ATPase-activating protein that competes with p23 and other co-chaperones for Hsp90 binding. Recombinant Aha1 was… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Activator of Hsp90 ATPase-1 (AHA1), Recombinant Protein

Full Product Name

Activator of Hsp90 ATPase-1 (AHA1), 19-337aa, Human, E Coli

Product Gene Name

AHA1 recombinant protein

Product Synonym Names

Activator of Hsp90 ATPase-1; AHA1; Activator of Hsp90 ATPase-1 (AHA1; 19-337); Activator of Hsp90 ATPase protein 1; Hsp90 co-chaperone AHA1; Activator of Hsp90 ATPase-1 Activator of 90 kDa heat shock protein ATPase homolog 1; Activator of heat shock 90kDa protein ATPase homolog 1; AHA 1; AHSA 1; AHSA1; C14orf3; HSPC322; p38.

Sequence

MATNVNNWHW TERDASNWST DKLKTLFLAV QVQNEEGKCE VTEVSKLDGE ASINNRKGKL IFFYEWSVKL NWTGTSKSGV QYKGHVEIPN LSDENSVDEV EISVSLAKDE PDTNLVALMK EEGVKLLREA MGIYISTLKT EFTQGMILPT MNGESVDPVG QPALKTEERK AKPAPSKTQA RPVGVKIPTC KITLKETFLT SPEELYRVFT TQELVQAFTH APATLEADRG GKFHMVDGNV SGEFTDLVPE KHIVMKWRFK SWPEGHFATI TLTFIDKNGE TELCMEGRGI PAPEEERTRQ GWQRYYFEGI KQTFGYGARL

Host

E Coli

Form/Format

Liquid. 20mM Tris pH 8.0, 2mM EDTA

Purity/Purification

> 95% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

36.1 kDa (320 aa), confirmed by MALDI-TOF.

OMIM

AJ243310 mRNA

3D Structure

ModBase 3D Structure for O95433

Antigen Species

Human

Endotoxin Level

< 1.0 EU per 1 microgram of protein (determined by LAL method)

Product Categories/Family for AHA1 recombinant protein

Heat Shock Proteins

Applications Tested/Suitable for AHA1 recombinant protein

SDS-PAGE

Product References and Citations for AHA1 recombinant protein

Meyer P., et al (2004). EMBO 23 (6): 1402-10; Siligardi G., et al (2004). J Biol Chem. 270 (50): 51989-98;

Other Notes

Small volumes of AHA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AHA1 purchase

MBS203038 is a recombinant protein targeting AHA1. Also known as Activator of Hsp90 ATPase-1 (AHA1), 19-337aa, Human, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for AHA1. It may not necessarily be applicable to this product.

NCBI GI #

6912280

NCBI GeneID

10598

NCBI Accession #

NP_036243

UniProt Primary Accession #

O95433

UniProt Secondary Accession #

Q96IL6; Q9P060; B2R9L2; B4DUR9

UniProt Related Accession #

O95433

GenBank Nucleotide #

NM_012111.2

NCBI Official Full Name

activator of 90 kDa heat shock protein ATPase homolog 1 isoform 1

NCBI Official Synonym Full Names

activator of HSP90 ATPase activity 1

NCBI Official Symbol

AHSA1

NCBI Official Synonym Symbols

p38; AHA1; hAha1; C14orf3

UniProt Protein Name

Activator of 90 kDa heat shock protein ATPase homolog 1

UniProt Synonym Protein Names

p38

Protein Family

ATPase

UniProt Gene Name

AHSA1

UniProt Synonym Gene Names

C14orf3; AHA1

NCBI Protein Information

activator of 90 kDa heat shock protein ATPase homolog 1

UniProt Comments for AHA1

Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360).

Research Articles on AHA1

1. These results suggest that differences in the middle domain of Hsp90alpha and Hsp90beta may be responsible for the isoform-specific interactions with selected proteins.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with AHA1 recombinant protein

Reference Product	PubMed Publications
PPID recombinant protein	>1 publications with AHA1 and PPID
STIP1 recombinant protein	>1 publications with AHA1 and STIP1

Pathways associated with AHA1 recombinant protein

Products by Pathway	Pathway Diagram
T-Cell Antigen Receptor (TCR) Pathway During Staphylococcus Aureus Infection antibodies	T-Cell Antigen Receptor (TCR) Pathway During Staphylococcus Aureus Infection Diagram

Diseases associated with AHA1 recombinant protein

Disease Name	Pubmed Publications
Fibrosis Antibodies	>4 publications with AHA1 and Fibrosis
Nervous System Diseases Antibodies	>1 publications with AHA1 and Nervous System Diseases
Congenital Abnormalities Antibodies	>1 publications with AHA1 and Congenital Abnormalities
Kidney Diseases Antibodies	>1 publications with AHA1 and Kidney Diseases

Organs/Tissues associated with AHA1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Spleen Antibodies	>1 publications with AHA1 and Spleen
Adipose Tissue Antibodies	>1 publications with AHA1 and Adipose Tissue
Thyroid Antibodies	>1 publications with AHA1 and Thyroid
Vascular Antibodies	>1 publications with AHA1 and Vascular
Kidney Antibodies	>1 publications with AHA1 and Kidney
Connective Tissue Antibodies	>1 publications with AHA1 and Connective Tissue
Blood Antibodies	>1 publications with AHA1 and Blood
Muscle Antibodies	>1 publications with AHA1 and Muscle
Mammary Gland Antibodies	>1 publications with AHA1 and Mammary Gland
Lung Antibodies	>1 publications with AHA1 and Lung