CXCL8 Recombinant Protein – Cat# MBS203086

Interleukin-8 (CXCL8) Recombinant Protein

Name: CXCL8 Recombinant Protein; Interleukin-8; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203086
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203086

Interleukin-8 (IL-8) is a chemokine, a member of the cytokine family that displays chemotactic activity for specific types of leukocytes. It is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. Many cell types, including… More details

$210 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin-8 (CXCL8), Recombinant Protein

Full Product Name

Interleukin-8, 23-99 aa, Human, E Coli

Product Gene Name

CXCL8 recombinant protein

Product Synonym Names

CXCL8; Neurophil chemotactic factor; NCF; Neutrophil activating protein; NAP; Monocyte derived neutrophil chemotactic factor; MDNCF; T-lymphocyte chemotactic factor; TCF; Granulocyte chemotactic protein; GCP; and Leukocyte adhension inhibitor; LAI; NAP 1; 3 10C; 310C; AMCF 1; AMCF1; b ENAP; Beta thromboglobulin like protein; CXC chemokine ligand 8; CXCL 8; Emoctakin; GCP 1; GCP1; Granulocyte chemotactic protein 1; IL 8; Inteleukin 8; Interleukin8; K 60; LECT; LuCT; Lymphocyte derived neutrophil activating factor; LYNAP; MDNCF; MDNCF a; MDNCF alpha; MONAP; Monocyte derived neutrophil activating protein; Monocyte derived neutrophil chemotactic factor; NAF; NAP1; Neutrophil activating factor; Neutrophil activating protein 1; Protein 3 10C; SCYB 8; SCYB8; T cell chemotactic factor; TSG 1; TSG1; il8

Sequence

MAVLPRSAKE LRCQCIKTYS KPFHPKFIKE LRVIESGPHC ANTEIIVKLS DGRELCLDPK ENWVQRVVEK FLKRAENS

Host

E Coli

Form/Format

Liquid. In phosphate buffer saline (pH 7.4)

Purity/Purification

> 95% by SDS-PAGE

Concentration

1 mg/ml (determined by BCA assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

9kDa (78aa), confirmed by MALDI-TOF.

OMIM

M17017 mRNA

3D Structure

ModBase 3D Structure for P10145

Antigen Species

Human

Endotoxin Level

< 1.0 EU per 1 microgram of protein (determined by LAL method)

Product Categories/Family for CXCL8 recombinant protein

Hormones & Cytokines

Applications Tested/Suitable for CXCL8 recombinant protein

SDS-PAGE

Product References and Citations for CXCL8 recombinant protein

Mukaida, N., et al. (1992)Microbiol. Immunol. 36, 773-789 ; Larsen, C.G., et al. (1989). Science, 243, 1464-1466; Baldwin ET., et al. (1990). J Biol Chem. 265 (12):6851-6853 ;

Other Notes

Small volumes of CXCL8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCL8 purchase

MBS203086 is a recombinant protein targeting CXCL8. Also known as Interleukin-8, 23-99 aa, Human, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCL8. It may not necessarily be applicable to this product.

NCBI GI #

10834978

NCBI GeneID

3576

NCBI Accession #

NP_000575

UniProt Primary Accession #

P10145

UniProt Secondary Accession #

Q6FGF6; Q6LAE6; Q96RG6; Q9C077; Q9UCE1; Q9UCR8; Q9UCR9; Q9UCS0; B2R4L8

UniProt Related Accession #

P10145

GenBank Nucleotide #

NM_000584.3

NCBI Official Full Name

interleukin-8 isoform 1

NCBI Official Synonym Full Names

C-X-C motif chemokine ligand 8

NCBI Official Symbol

CXCL8

NCBI Official Synonym Symbols

IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1

UniProt Protein Name

Interleukin-8

UniProt Synonym Protein Names

C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1

Protein Family

Interleukin

UniProt Gene Name

CXCL8

UniProt Synonym Gene Names

IL8; IL-8; GCP-1; MDNCF; MONAP; NAP-1; LYNAP; NAF

NCBI Protein Information

interleukin-8

NCBI Summary for CXCL8

The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Aug 2017]

UniProt Comments for CXCL8

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

Research Articles on CXCL8

1. IL-6, IL-8, and IL-10 circulating levels were shown to be higher in cases of infection. Further studies are needed to recommend a routine practice for predicting culture-confirmed bacterial infections.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CXCL8 recombinant protein

Reference Product	PubMed Publications
CCL5 recombinant protein	>373 publications with CXCL8 and CCL5
IL8 recombinant protein	>373 publications with CXCL8 and IL8
CXCL1 recombinant protein	>356 publications with CXCL8 and CXCL1
CXCR2 recombinant protein	>271 publications with CXCL8 and CXCR2
CXCR1 recombinant protein	>245 publications with CXCL8 and CXCR1
JUN recombinant protein	>201 publications with CXCL8 and JUN
CXCL12 recombinant protein	>112 publications with CXCL8 and CXCL12
IL6 recombinant protein	>105 publications with CXCL8 and IL6
IL1B recombinant protein	>39 publications with CXCL8 and IL1B
RELA recombinant protein	>28 publications with CXCL8 and RELA

Pathways associated with CXCL8 recombinant protein

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AGE-RAGE Signaling Pathway In Diabetic Complications antibodies	AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
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ATF-2 Transcription Factor Network Pathway antibodies	ATF-2 Transcription Factor Network Pathway Diagram
ATF4 Activates Genes Pathway antibodies	ATF4 Activates Genes Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Bladder Cancer Pathway antibodies	Bladder Cancer Pathway Diagram
Bladder Cancer Pathway antibodies	Bladder Cancer Pathway Diagram
Bladder Cancer Pathway antibodies	Bladder Cancer Pathway Diagram

Diseases associated with CXCL8 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>948 publications with CXCL8 and Inflammation
Pulmonary Disease, Chronic Obstructive Antibodies	>116 publications with CXCL8 and Pulmonary Disease, Chronic Obstructive
Arthritis, Rheumatoid Antibodies	>67 publications with CXCL8 and Arthritis, Rheumatoid
Adenocarcinoma Antibodies	>51 publications with CXCL8 and Adenocarcinoma
Breast Neoplasms Antibodies	>35 publications with CXCL8 and Breast Neoplasms
Pulmonary Fibrosis Antibodies	>26 publications with CXCL8 and Pulmonary Fibrosis
Colorectal Neoplasms Antibodies	>25 publications with CXCL8 and Colorectal Neoplasms
Fever Antibodies	>18 publications with CXCL8 and Fever
Ovarian Neoplasms Antibodies	>18 publications with CXCL8 and Ovarian Neoplasms
Reperfusion Injury Antibodies	>17 publications with CXCL8 and Reperfusion Injury

Organs/Tissues associated with CXCL8 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1016 publications with CXCL8 and Blood
Lung Antibodies	>355 publications with CXCL8 and Lung
Vascular Antibodies	>259 publications with CXCL8 and Vascular
Skin Antibodies	>168 publications with CXCL8 and Skin
Bone Antibodies	>92 publications with CXCL8 and Bone
Brain Antibodies	>83 publications with CXCL8 and Brain
Muscle Antibodies	>78 publications with CXCL8 and Muscle
Heart Antibodies	>77 publications with CXCL8 and Heart
Intestine Antibodies	>67 publications with CXCL8 and Intestine
Liver Antibodies	>65 publications with CXCL8 and Liver