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HSP105alpha Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203142

Hsp105 is a mammalian member of the HSP105/110 family, a diverged subgroup of the HSP70 family. HSP105 exists as two isoforms, alpha and beta. Hsp105 alpha associates with Hsp70/Hsc70 as complexes in vivo and regulates the chaperone activity of Hsp70/Hsc70… More details

$230 / 0.02 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HSP105alpha, Recombinant Protein
Full Product Name
HSP105alpha 1-858aa, Human, His tag, E Coli
Product Gene Name
HSP105alpha recombinant protein
Product Synonym Names
Heat shock 105kDa/110kDa protein 1; HSPH1; Heat shock 105kDa/110kDa protein 1; HSP105alpha; HSP105-alpha; Heat shock 105kDa/110kDa protein 1 Antigen NY CO 25; DKFZp686M05240; Heat shock 105kD; Heat shock 105kD alpha; Heat shock 105kD beta; Heat shock 105kDa protein; Heat shock 105kDa protein 1; Heat shock 110kDa protein; Heat shock protein 105 kDa; HSP105A; HSP105B; HSP110; HSPH 1; KIAA0201; NY CO 25.
Sequence
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMSVV GLDVGSQSCY IAVARAGGIE TIANEFSDRC TPSVISFGSK NRTIGVAAKN QQITHANNTV SNFKRFHGRA FNDPFIQKEK ENLSYDLVPL KNGGVGIKVM YMGEEHLFSV EQITAMLLTK LKETAENSLK KPVTDCVISV PSFFTDAERR SVLDAAQIVG LNCLRLMNDM TAVALNYGIY KQDLPSLDEK PRIVVFVDMG HSAFQVSACA FNKGKLKVLG TAFDPFLGGK NFDEKLVEHF CAEFKTKYKL DAKSKIRALL RLYQECEKLK KLMSSNSTDL PLNIECFMND KDVSGKMNRS QFEELCAELL QKIEVPLYSL LEQTHLKVED VSAVEIVGGA TRIPAVKERI AKFFGKDIST TLNADEAVAR GCALQCAILS PAFKVREFSV TDAVPFPISL IWNHDSEDTE GVHEVFSRNH AAPFSKVLTF LRRGPFELEA FYSDPQGVPY PEAKIGRFVV QNVSAQKDGE KSRVKVKVRV NTHGIFTIST ASMVEKVPTE ENEMSSEADM ECLNQRPPEN PDTDKNVQQD NSEAGTQPQV QTDAQQTSQS PPSPELTSEE NKIPDADKAN EKKVDQPPEA KKPKIKVVNV ELPIEANLVW QLGKDLLNMY IETEGKMIMQ DKLEKERNDA KNAVEEYVYE FRDKLCGPYE KFICEQDHQN FLRLLTETED WLYEEGEDQA KQAYVDKLEE LMKIGTPVKV RFQEAEERPK MFEELGQRLQ HYAKIAADFR NKDEKYNHID ESEMKKVEKS VNEVMEWMNN VMNAQAKKSL DQDPVVRAQE IKTKIKELNN TCEPVVTQPK PKIESPKLER TPNGPNIDKK EEDLEDKNNF GAEPPHQNGE CYPNEKNSVN MDLD
Host
E Coli
Form/Format
Liquid in 20 mM Tris-HCl buffer pH 8.0, 50 mM NaCl
Purity/Purification
> 90% by SDS-PAGE
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 2 degree C to 8 degree C for 1 week.
For long term storage, aliquot and store at -20 degree C to -80 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
100.9kDa (894aa)
OMIM
AB003333 mRNA
3D Structure
ModBase 3D Structure for Q92598
Tag Information
His-tag
Domain
1-858aa

Product Categories/Family for HSP105alpha recombinant protein

Heat Shock Proteins
Applications Tested/Suitable for HSP105alpha recombinant protein
SDS-PAGE

SDS-Page of HSP105alpha recombinant protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
HSP105alpha Recombinant Protein – Cat# MBS203142

Product References and Citations for HSP105alpha recombinant protein

Yamagishi N., et al. (2006) Exp Cell Res. 312 (17):3215-23.; Wang XY., et al. (2001) J Immunol. 166 (1):490-7.

Other Notes

Small volumes of HSP105alpha recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HSP105alpha purchase

MBS203142 is a recombinant protein targeting HSP105alpha. Also known as HSP105alpha 1-858aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for HSP105alpha. It may not necessarily be applicable to this product.

NCBI GI #
42544159
NCBI GeneID
10808
NCBI Accession #
NP_006635
UniProt Primary Accession #
Q92598
UniProt Secondary Accession #
O95739; Q5TBM6; Q5TBM7; Q5TBM8; Q9UPC4; B4DYH1
UniProt Related Accession #
Q92598
GenBank Nucleotide #
NM_006644.3
NCBI Official Full Name
heat shock protein 105 kDa isoform 1
NCBI Official Synonym Full Names
heat shock protein family H (Hsp110) member 1
NCBI Official Symbol
HSPH1
NCBI Official Synonym Symbols
HSP105; HSP105A; HSP105B; NY-CO-25
UniProt Protein Name
Heat shock protein 105 kDa
UniProt Synonym Protein Names
Antigen NY-CO-25; Heat shock 110 kDa protein
UniProt Gene Name
HSPH1
UniProt Synonym Gene Names
HSP105; HSP110; KIAA0201
NCBI Protein Information
heat shock protein 105 kDa

NCBI Summary for HSP105alpha

This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]
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UniProt Comments for HSP105alpha

Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities ().
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Research Articles on HSP105alpha

1. Established heat shock protein 110 (HSP110) as a prognostic biomarker of colorectal carcinomas (CRCs) with microsatellite instability-high (MSI-H) by considering the intratumoral heterogeneity of HSP110 expression. The HSP110wt-low MSI-H CRCs were significantly correlated with larger deletions in the HSP110 T17 mononucleotide repeat (>/=4 bp; p < 0.001).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HSP105alpha recombinant protein

 Reference Product  PubMed Publications
 DNAJB1 recombinant protein  >10 publications with HSP105alpha and DNAJB1
 DNAJA1 recombinant protein  >8 publications with HSP105alpha and DNAJA1
 HSPA8 recombinant protein  >7 publications with HSP105alpha and HSPA8
 HSPA4 recombinant protein  >6 publications with HSP105alpha and HSPA4
 DNAJB4 recombinant protein  >4 publications with HSP105alpha and DNAJB4
 HSPA2 recombinant protein  >3 publications with HSP105alpha and HSPA2
 HSP90AA1 recombinant protein  >2 publications with HSP105alpha and HSP90AA1
 HSPA9 recombinant protein  >1 publications with HSP105alpha and HSPA9

Pathways associated with HSP105alpha recombinant protein

 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Regulation Of HSF1-mediated Heat Shock Response Pathway antibodies  Regulation Of HSF1-mediated Heat Shock Response Pathway Diagram
 Scavenging By Class F Receptors Pathway antibodies  Scavenging By Class F Receptors Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram

Diseases associated with HSP105alpha recombinant protein

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >8 publications with HSP105alpha and Adenocarcinoma
 Inflammation Antibodies  >5 publications with HSP105alpha and Inflammation
 Necrosis Antibodies  >4 publications with HSP105alpha and Necrosis
 Disease Models, Animal Antibodies  >3 publications with HSP105alpha and Disease Models, Animal
 Nervous System Diseases Antibodies  >3 publications with HSP105alpha and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >3 publications with HSP105alpha and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >2 publications with HSP105alpha and Neoplasms, Experimental
 Heart Diseases Antibodies  >2 publications with HSP105alpha and Heart Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with HSP105alpha and Carcinoma, Hepatocellular
 Cell Transformation, Neoplastic Antibodies  >1 publications with HSP105alpha and Cell Transformation, Neoplastic

Organs/Tissues associated with HSP105alpha recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12 publications with HSP105alpha and Blood
 Brain Antibodies  >9 publications with HSP105alpha and Brain
 Skin Antibodies  >8 publications with HSP105alpha and Skin
 Intestine Antibodies  >4 publications with HSP105alpha and Intestine
 Liver Antibodies  >3 publications with HSP105alpha and Liver
 Bone Antibodies  >3 publications with HSP105alpha and Bone
 Lymph Node Antibodies  >3 publications with HSP105alpha and Lymph Node
 Pancreas Antibodies  >3 publications with HSP105alpha and Pancreas
 Lymph Antibodies  >3 publications with HSP105alpha and Lymph
 Testis Antibodies  >3 publications with HSP105alpha and Testis
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