SCF Recombinant Protein

Name: SCF Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203151
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203151

Stem Cell Factor (SCF) is a glycoprotein that plays a key role in hematopoiesis acting both as a positive and negative regulator, often in synergy with other cytokines. SCF binds to and activates the SCF receptor (SCFR), a receptor tyrosine kinase. SCF… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SCF, Recombinant Protein

Full Product Name

mouse SCF, 26-189aa, mouse, E Coli

Product Gene Name

SCF recombinant protein

Product Synonym Names

Stem cell factor; glycosylation inhibiting factor (GIF); GLIF; MMIF; SCF; Kitl; Clo; Con; contrasted; Gb; Kitlg; Mgf; SF; Sl; SLF; Steel; mouse SCF; Stem cell factor; Stem cell factor

Sequence

MKEICGNPVT DNVKDITKLV ANLPNDYMIT LNYVAGMDVL PSHCWLRDMV IQLSLSLTTL LDKFSNISEG LSNYSIIDKL GKIVDDLVLC MEENAPKNIK ESPKRPETRS FTPEEFFSIF NRSIDAFKDF MVASDTSDCV LSSTLGPEKD SRVSVTKPFM LPPVA

Host

E Coli

Form/Format

Liquid. In phosphate buffer saline (pH 7.4) containing 10% glycerol

Purity/Purification

> 95% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

18 kDa (165 aa), confirmed by MALDI-TOF.

3D Structure

ModBase 3D Structure for P20826

Antigen Species

Human

Product Categories/Family for SCF recombinant protein

Hormones & Cytokines

Applications Tested/Suitable for SCF recombinant protein

SDS-PAGE

Product References and Citations for SCF recombinant protein

Zhang Z., et al. (2000). Proc. Natl. Acad. Sci. u.S.A. 97, 7732.; Okada S, et al. (1992). Nippon Rinsho, 50, 1872.;

Other Notes

Small volumes of SCF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SCF purchase

MBS203151 is a recombinant protein targeting SCF. Also known as mouse SCF, 26-189aa, mouse, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SCF. It may not necessarily be applicable to this product.

NCBI GI #

7305267

NCBI GeneID

17311

NCBI Accession #

NP_038626

UniProt Primary Accession #

P20826

UniProt Secondary Accession #

P97332; Q3TNJ7; Q62524; Q64222; Q921N5

UniProt Related Accession #

P20826

GenBank Nucleotide #

NM_013598.3

NCBI Official Full Name

kit ligand isoform 1

NCBI Official Synonym Full Names

kit ligand

NCBI Official Symbol

Kitl

NCBI Official Synonym Symbols

Gb; SF; Sl; Clo; Con; Mgf; SCF; SLF; blz; Kitlg; contrasted

UniProt Protein Name

Kit ligand

UniProt Synonym Protein Names

Hematopoietic growth factor KL; Mast cell growth factor; MGF

Protein Family

SCF-associated factor

UniProt Gene Name

Kitlg

UniProt Synonym Gene Names

Kitl; Mgf; Sl; Slf; MGF; SCF; sKITLG

NCBI Protein Information

kit ligand

UniProt Comments for SCF

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

Research Articles on SCF

1. In vitro, SCF induced the phosphorylation of p38 MAPK and cofilin, leading to the migration of cardiac stem cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SCF recombinant protein

Reference Product	PubMed Publications
Kit recombinant protein	>113 publications with SCF and Kit
Stat3 recombinant protein	>1 publications with SCF and Stat3

Pathways associated with SCF recombinant protein

Products by Pathway	Pathway Diagram
ARMS-mediated Activation Pathway antibodies	ARMS-mediated Activation Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Downstream Signal Transduction Pathway antibodies	Downstream Signal Transduction Pathway Diagram

Diseases associated with SCF recombinant protein

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>10 publications with SCF and Disease Models, Animal
Neoplasms, Experimental Antibodies	>6 publications with SCF and Neoplasms, Experimental
Inflammation Antibodies	>6 publications with SCF and Inflammation
Infertility, Male Antibodies	>5 publications with SCF and Infertility, Male
Embryo Loss Antibodies	>4 publications with SCF and Embryo Loss
Cell Transformation, Neoplastic Antibodies	>3 publications with SCF and Cell Transformation, Neoplastic
Fibrosis Antibodies	>3 publications with SCF and Fibrosis
Weight Loss Antibodies	>3 publications with SCF and Weight Loss
Skin Neoplasms Antibodies	>3 publications with SCF and Skin Neoplasms
Lung Diseases Antibodies	>3 publications with SCF and Lung Diseases

Organs/Tissues associated with SCF recombinant protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>37 publications with SCF and Bone
Ovary Antibodies	>34 publications with SCF and Ovary
Skin Antibodies	>26 publications with SCF and Skin
Bone Marrow Antibodies	>26 publications with SCF and Bone Marrow
Testis Antibodies	>21 publications with SCF and Testis
Liver Antibodies	>9 publications with SCF and Liver
Embryonic Tissue Antibodies	>9 publications with SCF and Embryonic Tissue
Heart Antibodies	>7 publications with SCF and Heart
Muscle Antibodies	>6 publications with SCF and Muscle
Spleen Antibodies	>5 publications with SCF and Spleen