CPLX1 Recombinant Protein – Cat# MBS203173

Complexin1 (CPLX1) Recombinant Protein

Name: CPLX1 Recombinant Protein; Complexin1; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203173
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203173

Complexin1 belongs to a family of SNARE complex binding proteins that were suggested to be either facilitators or inhibitors of vesicle exocytosis. Complexin 1 exhibits reduced Ca2+-triggered fast neurotransmitter release at hippocampal glutamatergic… More details

$210 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Complexin1 (CPLX1), Recombinant Protein

Full Product Name

Complexin1, 1-134aa, Human, His tag, E Coli

Product Gene Name

CPLX1 recombinant protein

Product Synonym Names

CPXL1; CPX1; Synaphin-2; Complexin 1; Complexin I; CPX1; Synaphin 2

Sequence

MGSSHHHHHH SSGLVPRGSH MEFVMKQALG GATKDMGKML GGDEEKDPDA AKKEEERQEA LRQAEEERKA KYAKMEAERE AVRQGIRDKY GIKKKEEREA EAQAAMEANS EGSLTRPKKA IPPGCGDEVE EEDESILDTV IKYLPGPLQD MLKK

Host

E Coli

Form/Format

Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol

Purity/Purification

> 90% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

17.1 kDa (154 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)

OMIM

AF022383 mRNA

3D Structure

ModBase 3D Structure for O14810

Antigen Species

Human

Tag Information

His-tag

Endotoxin Level

< 1.0 EU per 1 microgram of protein (determined by LAL method)

Product Categories/Family for CPLX1 recombinant protein

Neuroscience

Applications Tested/Suitable for CPLX1 recombinant protein

SDS-PAGE

Product References and Citations for CPLX1 recombinant protein

Salimi K, et al. (2008) Synapse, 273-82; Giraudo CG, et al. (2006) Science, 676-80; Tang J, et al. (2006) Cell, 1175-87;

Other Notes

Small volumes of CPLX1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CPLX1 purchase

MBS203173 is a recombinant protein targeting CPLX1. Also known as Complexin1, 1-134aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CPLX1. It may not necessarily be applicable to this product.

NCBI GI #

5729781

NCBI GeneID

10815

NCBI Accession #

NP_006642

UniProt Primary Accession #

O14810

UniProt Secondary Accession #

A6NI80; B2R4R5; D3DVN3; F1T0G1

UniProt Related Accession #

O14810

GenBank Nucleotide #

NM_006651.3

NCBI Official Full Name

complexin-1

NCBI Official Synonym Full Names

complexin 1

NCBI Official Symbol

CPLX1

NCBI Official Synonym Symbols

CPX1; CPX-I

UniProt Protein Name

Complexin-1

UniProt Synonym Protein Names

Complexin I; CPX I; Synaphin-2

UniProt Gene Name

CPLX1

UniProt Synonym Gene Names

CPX I

NCBI Protein Information

complexin-1

NCBI Summary for CPLX1

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]

UniProt Comments for CPLX1

Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.

Research Articles on CPLX1

1. Homozygous CPLX1 variants were identified in three patients with severe infantile myoclonic epilepsy and ID.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CPLX1 recombinant protein

Reference Product	PubMed Publications
SYT1 recombinant protein	>3 publications with CPLX1 and SYT1
VAMP2 recombinant protein	>2 publications with CPLX1 and VAMP2
STX1A recombinant protein	>2 publications with CPLX1 and STX1A
SNAP25 recombinant protein	>2 publications with CPLX1 and SNAP25
RAB3A recombinant protein	>1 publications with CPLX1 and RAB3A

Pathways associated with CPLX1 recombinant protein

Products by Pathway	Pathway Diagram
Acetylcholine Neurotransmitter Release Cycle Pathway antibodies	Acetylcholine Neurotransmitter Release Cycle Pathway Diagram
Dopamine Neurotransmitter Release Cycle Pathway antibodies	Dopamine Neurotransmitter Release Cycle Pathway Diagram
GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies	GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
Glutamate Neurotransmitter Release Cycle Pathway antibodies	Glutamate Neurotransmitter Release Cycle Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Neurotransmitter Release Cycle Pathway antibodies	Neurotransmitter Release Cycle Pathway Diagram
Norepinephrine Neurotransmitter Release Cycle Pathway antibodies	Norepinephrine Neurotransmitter Release Cycle Pathway Diagram
Serotonin Neurotransmitter Release Cycle Pathway antibodies	Serotonin Neurotransmitter Release Cycle Pathway Diagram
Synaptic Vesicle Pathway antibodies	Synaptic Vesicle Pathway Diagram
Synaptic Vesicle Cycle Pathway antibodies	Synaptic Vesicle Cycle Pathway Diagram

Diseases associated with CPLX1 recombinant protein

Disease Name	Pubmed Publications
Schizophrenia Antibodies	>11 publications with CPLX1 and Schizophrenia
Brain Diseases Antibodies	>5 publications with CPLX1 and Brain Diseases
Abnormalities, Multiple Antibodies	>4 publications with CPLX1 and Abnormalities, Multiple
Memory Disorders Antibodies	>3 publications with CPLX1 and Memory Disorders
Wolf-Hirschhorn Syndrome Antibodies	>3 publications with CPLX1 and Wolf-Hirschhorn Syndrome
Neurobehavioral Manifestations Antibodies	>3 publications with CPLX1 and Neurobehavioral Manifestations
Cognition Disorders Antibodies	>2 publications with CPLX1 and Cognition Disorders
Learning Disorders Antibodies	>2 publications with CPLX1 and Learning Disorders
Growth Disorders Antibodies	>2 publications with CPLX1 and Growth Disorders
Atrophy Antibodies	>2 publications with CPLX1 and Atrophy

Organs/Tissues associated with CPLX1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>17 publications with CPLX1 and Brain
Blood Antibodies	>3 publications with CPLX1 and Blood
Eye Antibodies	>2 publications with CPLX1 and Eye
Pancreas Antibodies	>1 publications with CPLX1 and Pancreas