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CDC37 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203185

CDC37, an essential gene in Saccharomyces cerevisiae, interacts genetically with multiple protein kinases. Cdc37 associates with the heat-shock protein 90 (Hsp90) molecular chaperone as one of several auxiliary proteins that are collectively referred to as… More details

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Product Overview

Online Datasheet in PDF
Product Name
CDC37, Recombinant Protein
Full Product Name
CDC37, 1-378aa, Human, E Coli
Product Gene Name
Product Synonym Names
Cell division cycle 37 homolog; P50CDC37; CDC37; Cell division cycle 37 homolog; Cell division cycle 37 homolog S cerevisiae hypothetical protein CDC37; CDC 37; CDC37 cell division cycle 37 homolog; Cdc37 homolog; CDC37 protein; Hsp90 chaperone protein kinase targeting subunit; Hsp90 chaperone protein kinase targeting subunit p50Cdc37; Hsp90 co chaperone Cdc37; p50; p50Cdc37.
Sequence
MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL DRGCRECKRK VAECQRKLKE LEVAEGGKAE LERLQAEAQQ LRKEERSWEQ KLEEMRKKEK SMPWNVDTLS KDGFSKSMVN TKPEKTEEDS EEVREQKHKT FVEKYEKQIK HFGMLRRWDD SQKYLSDNVH LVCEETANYL VIWCIDLEVE EKCALMEQVA HQTIVMQFIL ELAKSLKVDP RACFRQFFTK IKTADRQYME GFNDELEAFK ERVRGRAKLR IEKAMKEYEE EERKKRLGPG GLDPVEVYES LPEELQKCFD VKDVQMLQDA ISKMDPTDAK YHMQRCIDSG LWVPNSKASE AKEGEEAGPG DPLLEAVPKT GDEKDVSV
Host
E Coli
Form/Format
Liquid in 20mM Tris pH 8.0, 10% glycerol Molecular Weight: 44.4kDa (378aa)
Purity/Purification
> 95% by SDS-PAGE
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
44.4Da (378aa), confirmed by MALDI-TOF.
OMIM
U43077 mRNA
3D Structure
ModBase 3D Structure for Q16543
Antigen Species
Human
Endotoxin Level
< 1.0 EU per 1 microgram of protein (determined by LAL method)

Product Categories/Family for CDC37 recombinant protein

Applications Tested/Suitable for CDC37 recombinant protein
SDS-PAGE

Product References and Citations for CDC37 recombinant protein

Boudeau J., (2003) Biochem J. 370 (3):849-57; Abbas-Terki T., (2002) Biol Chem. 383 (9):1335-42;

Other Notes

Small volumes of CDC37 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDC37 purchase

MBS203185 is a recombinant protein targeting CDC37. Also known as CDC37, 1-378aa, Human, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CDC37. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
hsp90 co-chaperone Cdc37
NCBI Official Synonym Full Names
cell division cycle 37
NCBI Official Symbol
CDC37
NCBI Official Synonym Symbols
P50CDC37
UniProt Protein Name
Hsp90 co-chaperone Cdc37
UniProt Synonym Protein Names
Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37
Protein Family
UniProt Gene Name
CDC37
UniProt Synonym Gene Names
CDC37A
NCBI Protein Information
hsp90 co-chaperone Cdc37

NCBI Summary for CDC37

The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
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UniProt Comments for CDC37

Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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