HIP/ST13 Recombinant Protein

Name: HIP/ST13 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203191
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203191

Hip (Hsc70-interacting protein), also known as ST13, is a co-chaperone to the major heat shock proteins, Hsp70 and Hsp90, and appears in early receptor complexes. Through mutual binding to both Hsp70 and Hsp90, Hip functions as an adaptor that can integrate… More details

$210 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Hip/ST13, Recombinant Protein

Full Product Name

Hip/ST13, 1-369aa, Human, E Coli

Product Gene Name

Hip/ST13 recombinant protein

Product Synonym Names

Hsc70-interacting protein; ST13; HOP; SNC6; FAM10A1; Hsc70-interacting protein

Sequence

MDPRKVNELR AFVKMCKQDP SVLHTEEMRF LREWVESMGG KVPPATQKAK SEENTKEEKP DSKKVEEDLK ADEPSSEESD LEIDKEGVIE PDTDAPQEMG DENAEITEEM MDQANDKKVA AIEALNDGEL QKAIDLFTDA IKLNPRLAIL YAKRASVFVK LQKPNAAIRD CDRAIEINPD SAQPYKWRGK AHRLLGHWEE AAHDLALACK LDYDEDASAM LKEVQPRAQK IAEHRRKYER KREEREIKER IERVKKAREE HERAQREEEA RRQSGAQYGS FPGGFPGGMP GNFPGGMPGM GGGMPGMAGM PGLNEILSDP EVLAAMQDPE VMVAFQDVAQ NPANMSKYQS NPKVMNLISK LSAKFGGQA

Host

E Coli

Form/Format

Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 0.1M NaCl, 10% glycerol

Purity/Purification

> 90% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

41.3 kDa (369aa), confirmed by MALDI-TOF.

OMIM

U28918 mRNA

3D Structure

ModBase 3D Structure for P50502

Antigen Species

Human

Endotoxin Level

< 1.0 EU per 1 microgram of protein (determined by LAL method)

Product Categories/Family for Hip/ST13 recombinant protein

Heat Shock Proteins

Applications Tested/Suitable for Hip/ST13 recombinant protein

SDS-PAGE

Product References and Citations for Hip/ST13 recombinant protein

Nelson GM., et al. (2004). Mol Endocrinol. 18 (7):1620-30; Johnson BD., et al. (1998). J Biol chem. 273 (6):3679-86;

Other Notes

Small volumes of Hip/ST13 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Hip/ST13 purchase

MBS203191 is a recombinant protein targeting Hip/ST13. Also known as Hip/ST13, 1-369aa, Human, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Hip/ST13. It may not necessarily be applicable to this product.

NCBI GI #

19923193

NCBI GeneID

6767

NCBI Accession #

NP_003923

UniProt Primary Accession #

P50502

UniProt Secondary Accession #

O14999; Q2TU77

UniProt Related Accession #

P50502

GenBank Nucleotide #

NM_003932.4

NCBI Official Full Name

hsc70-interacting protein isoform 1

NCBI Official Synonym Full Names

ST13, Hsp70 interacting protein

NCBI Official Symbol

ST13

NCBI Official Synonym Symbols

HIP; HOP; P48; AAG2; SNC6; HSPABP; FAM10A1; FAM10A4; HSPABP1; PRO0786

UniProt Protein Name

Hsc70-interacting protein

UniProt Synonym Protein Names

Aging-associated protein 2; Progesterone receptor-associated p48 protein; Protein FAM10A1; Putative tumor suppressor ST13; Renal carcinoma antigen NY-REN-33; Suppression of tumorigenicity 13 protein

UniProt Gene Name

ST13

UniProt Synonym Gene Names

AAG2; FAM10A1; HIP; SNC6; Hip

NCBI Protein Information

hsc70-interacting protein

NCBI Summary for Hip/ST13

The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

UniProt Comments for Hip/ST13

One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins ().

Research Articles on Hip/ST13

1. A novel susceptibility gene, ST13, coding for a cochaperone of the glucocorticoid receptor, is associated with exacerbations in asthmatic children and young adults despite their ICS use.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Hip/ST13 recombinant protein

Reference Product	PubMed Publications
HSPA1A recombinant protein	>2 publications with Hip/ST13 and HSPA1A
HSPA8 recombinant protein	>2 publications with Hip/ST13 and HSPA8
HSPA6 recombinant protein	>1 publications with Hip/ST13 and HSPA6

Pathways associated with Hip/ST13 recombinant protein

Products by Pathway	Pathway Diagram
Cellular Response To Heat Stress Pathway antibodies	Cellular Response To Heat Stress Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Regulation Of HSF1-mediated Heat Shock Response Pathway antibodies	Regulation Of HSF1-mediated Heat Shock Response Pathway Diagram

Diseases associated with Hip/ST13 recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>5 publications with Hip/ST13 and Nervous System Diseases
Movement Disorders Antibodies	>4 publications with Hip/ST13 and Movement Disorders
Skin Diseases Antibodies	>1 publications with Hip/ST13 and Skin Diseases
Cardiovascular Diseases Antibodies	>1 publications with Hip/ST13 and Cardiovascular Diseases
Liver Diseases Antibodies	>1 publications with Hip/ST13 and Liver Diseases
Nerve Degeneration Antibodies	>1 publications with Hip/ST13 and Nerve Degeneration
Fibrosis Antibodies	>1 publications with Hip/ST13 and Fibrosis
Necrosis Antibodies	>1 publications with Hip/ST13 and Necrosis

Organs/Tissues associated with Hip/ST13 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>8 publications with Hip/ST13 and Blood
Liver Antibodies	>3 publications with Hip/ST13 and Liver
Lung Antibodies	>2 publications with Hip/ST13 and Lung
Kidney Antibodies	>2 publications with Hip/ST13 and Kidney
Lymph Antibodies	>2 publications with Hip/ST13 and Lymph
Stomach Antibodies	>2 publications with Hip/ST13 and Stomach
Lymph Node Antibodies	>2 publications with Hip/ST13 and Lymph Node
Intestine Antibodies	>2 publications with Hip/ST13 and Intestine
Brain Antibodies	>2 publications with Hip/ST13 and Brain
Thyroid Antibodies	>1 publications with Hip/ST13 and Thyroid