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HSP90B1 (GRP94) (HSP90B1) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203192

GRP94, also known as Heat shock protein 90kDa beta, member 1 (HSP90B1), is an abundant resident endoplasmic reticulum (ER) lumenal stress protein which together with cytosolic Hsp90 belongs to the Hsp90 family of molecular chaperones. It plays an important… More details

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Product Overview

Online Datasheet in PDF
Product Name
HSP90B1 (GRP94), Recombinant Protein
Full Product Name
HSP90B1 (GRP94), 22-803aa, Human, His tag, E Coli
Product Gene Name
HSP90B1 recombinant protein
Product Synonym Names
94 kDa glucose-regulated protein; 94 kDa glucose-regulated protein; HSP90B1; GP96; TRA1; Tumor rejection antigen 1; GRP94; 94 kDa glucose-regulated protein 94 kDa glucose regulated protein; ECGP; Endoplasmin; Endothelial cell (HBMEC) glycoprotein; Glucose regulated protein 94kDa; gp96; gp96 homolog; GRP 9; Heat shock protein 90 kDa beta member 1; Stress inducible tumor rejection antigen GP96; Tumor rejection antigen gp96.
Sequence
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMDDE VDVDGTVEED LGKSREGSRT DDEVVQREEE AIQLDGLNAS QIRELREKSE KFAFQAEVNR MMKLIINSLY KNKEIFLREL ISNASDALDK IRLISLTDEN ALSGNEELTV KIKCDKEKNL LHVTDTGVGM TREELVKNLG TIAKSGTSEF LNKMTEAQED GQSTSELIGQ FGVGFYSAFL VADKVIVTSK HNNDTQHIWE SDSNEFSVIA DPRGNTLGRG TTITLVLKEE ASDYLELDTI KNLVKKYSQF INFPIYVWSS KTETVEEPME EEEAAKEEKE ESDDEAAVEE EEEEKKPKTK KVEKTVWDWE LMNDIKPIWQ RPSKEVEEDE YKAFYKSFSK ESDDPMAYIH FTAEGEVTFK SILFVPTSAP RGLFDEYGSK KSDYIKLYVR RVFITDDFHD MMPKYLNFVK GVVDSDDLPL NVSRETLQQH KLLKVIRKKL VRKTLDMIKK IADDKYNDTF WKEFGTNIKL GVIEDHSNRT RLAKLLRFQS SHHPTDITSL DQYVERMKEK QDKIYFMAGS SRKEAESSPF VERLLKKGYE VIYLTEPVDE YCIQALPEFD GKRFQNVAKE GVKFDESEKT KESREAVEKE FEPLLNWMKD KALKDKIEKA VVSQRLTESP CALVASQYGW SGNMERIMKA QAYQTGKDIS TNYYASQKKT FEINPRHPLI RDMLRRIKED EDDKTVLDLA VVLFETATLR SGYLLPDTKA YGDRIERMLR LSLNIDPDAK VEEEPEEEPE ETAEDTTEDT EQDEDEEMDV GTDEEEETAK ESTAEKDEL
Host
E Coli
Form/Format
Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 1 mM DTT, 1mM EDTA, 0.1M NaCl, 10% glycerol
Purity/Purification
> 90% by SDS-PAGE
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 2°C to 8°C for 1 week.
For long term storage, aliquot and store at -20°C to -80°C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
94.4 kDa (819aa)
OMIM
X15187 mRNA
3D Structure
ModBase 3D Structure for P14625
Tag
His-tag
Domain
22-803aa

Product Categories/Family for HSP90B1 recombinant protein

Heat Shock Proteins
Applications Tested/Suitable for HSP90B1 recombinant protein
SDS-PAGE

SDS-Page of HSP90B1 recombinant protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
HSP90B1 Recombinant Protein – Cat# MBS203192

Product References and Citations for HSP90B1 recombinant protein

Randow F., et al. (2001). Nat Cell Biol. 3 (10):E231.; Li Z., et al. (2002). Front Biosci. 7:d731-51. ;

Other Notes

Small volumes of HSP90B1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HSP90B1 purchase

MBS203192 is a recombinant protein targeting HSP90B1. Also known as HSP90B1 (GRP94), 22-803aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for HSP90B1. It may not necessarily be applicable to this product.

NCBI GI #
4507677
NCBI GeneID
7184
NCBI Accession #
NP_003290
UniProt Primary Accession #
P14625
UniProt Secondary Accession #
Q96A97
UniProt Related Accession #
P14625
GenBank Nucleotide #
NM_003299.2
NCBI Official Full Name
endoplasmin
NCBI Official Synonym Full Names
heat shock protein 90 beta family member 1
NCBI Official Symbol
HSP90B1
NCBI Official Synonym Symbols
ECGP; GP96; TRA1; GRP94; HEL35; HEL-S-125m
UniProt Protein Name
Endoplasmin
UniProt Synonym Protein Names
94 kDa glucose-regulated protein; GRP-94; Heat shock protein 90 kDa beta member 1; Tumor rejection antigen 1; gp96 homolog
Protein Family
Endoplasmin
UniProt Gene Name
HSP90B1
UniProt Synonym Gene Names
GRP94; TRA1; GRP-94
NCBI Protein Information
endoplasmin

NCBI Summary for HSP90B1

This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]
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UniProt Comments for HSP90B1

Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.

Research Articles on HSP90B1

1. High GRP94 expression is associated with endometrioid adenocarcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HSP90B1 recombinant protein

 Reference Product  PubMed Publications
 HSPA5 recombinant protein  >14 publications with HSP90B1 and HSPA5
 CALR recombinant protein  >4 publications with HSP90B1 and CALR
 PDIA6 recombinant protein  >2 publications with HSP90B1 and PDIA6
 HYOU1 recombinant protein  >2 publications with HSP90B1 and HYOU1

Pathways associated with HSP90B1 recombinant protein

 Products by Pathway  Pathway Diagram
 ATF6 (ATF6-alpha) Activates Chaperone Genes Pathway antibodies  ATF6 (ATF6-alpha) Activates Chaperone Genes Pathway Diagram
 ATF6 (ATF6-alpha) Activates Chaperones Pathway antibodies  ATF6 (ATF6-alpha) Activates Chaperones Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Fluid Shear Stress And Atherosclerosis Pathway antibodies  Fluid Shear Stress And Atherosclerosis Pathway Diagram
 Fluid Shear Stress And Atherosclerosis Pathway antibodies  Fluid Shear Stress And Atherosclerosis Pathway Diagram
 IL-17 Signaling Pathway antibodies  IL-17 Signaling Pathway Diagram
 IL-17 Signaling Pathway antibodies  IL-17 Signaling Pathway Diagram

Diseases associated with HSP90B1 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >6 publications with HSP90B1 and Inflammation
 Liver Diseases Antibodies  >5 publications with HSP90B1 and Liver Diseases
 Disease Models, Animal Antibodies  >5 publications with HSP90B1 and Disease Models, Animal
 Lung Diseases Antibodies  >5 publications with HSP90B1 and Lung Diseases
 Liver Neoplasms Antibodies  >4 publications with HSP90B1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >4 publications with HSP90B1 and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >3 publications with HSP90B1 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >3 publications with HSP90B1 and Lung Neoplasms
 Testicular Diseases Antibodies  >2 publications with HSP90B1 and Testicular Diseases
 Hyperplasia Antibodies  >2 publications with HSP90B1 and Hyperplasia

Organs/Tissues associated with HSP90B1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with HSP90B1 and Blood
 Bone Antibodies  >9 publications with HSP90B1 and Bone
 Brain Antibodies  >8 publications with HSP90B1 and Brain
 Liver Antibodies  >7 publications with HSP90B1 and Liver
 Lymph Node Antibodies  >5 publications with HSP90B1 and Lymph Node
 Bone Marrow Antibodies  >5 publications with HSP90B1 and Bone Marrow
 Lung Antibodies  >4 publications with HSP90B1 and Lung
 Pancreas Antibodies  >3 publications with HSP90B1 and Pancreas
 Prostate Antibodies  >3 publications with HSP90B1 and Prostate
 Testis Antibodies  >3 publications with HSP90B1 and Testis
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