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2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2032180
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MBS2032180 is an antibody targeting CNP. Also known as 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP) Polyclonal Antibody. Reactive in Human, Mouse, Rat, Pig. Host: Rabbit. More details

$215 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP), Polyclonal Antibody
Full Product Name
2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP) Polyclonal Antibody
Product Gene Name
anti-CNP antibody
Product Synonym Names
2, 3CNP; 2, 3-CNP; CNPCNP1; Cyclic-CMP Phosphodiesterase; 2', 3'-Cyclic AMP Phosphodiesterase; CNPase; 2':3'-CNMP-3'-ase
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Pig
Form/Format
Supplied as solution form in PBS, pH7.4 containing 0.02% NaN3, 50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against CNP. It has been selected for its ability to recognize CNP in immunohistochemical staining and western blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: CNP (MBS2032180)
Immunogen: CNP (MBS2033046)
Matching Pairs
Unconjugated Antibody: CNP (MBS2032180)
APC-CY7 Conjugated Antibody: CNP (MBS2064429)
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Molecular Weight
45,099 Da
3D Structure
ModBase 3D Structure for P09543
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunoglobulin Type
IgG
Conjugate
No Conjugate
Cross Reactivity
Human
Organism Species
Human
Fragment
CNP (Leu186~Ile421)
Quality Control
Content: The quality control contains recombinant CNP (Leu186~Ile421) disposed in loading buffer.
Usage: 10uL per well when 3,3'-Diaminobenzidine(DAB) as the substrate.
5uL per well when used in enhanced chemilumescent (ECL).
Note: The quality control is specifically manufactured as the positive control.Not used for other purposes.
Loading Buffer: 100mM Tris(pH8.8), 2% SDS, 200mM NaCl, 50% glycerol,BPB 0.01%, NaN3 0.02%.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2064431
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-CNP antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
Application Notes for anti-CNP antibody
Western Blot: 1:50-400
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-CNP antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-CNP Polyclonal Antibody – Cat# MBS2032180

Immunohistochemistry (IHC) of anti-CNP antibody

DAB staining on fromalin fixed paraffin- embedded brain tissue)
Rabbit Anti-CNP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2032180

Other Notes

Small volumes of anti-CNP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CNP. It may not necessarily be applicable to this product.

NCBI GI #
1057503192
NCBI GeneID
1267
NCBI Accession #
NP_001317145.1
UniProt Primary Accession #
P09543
UniProt Related Accession #
P09543
GenBank Nucleotide #
NM_001330216.1
NCBI Official Full Name
2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform 2
NCBI Official Synonym Full Names
2',3'-cyclic nucleotide 3' phosphodiesterase
NCBI Official Symbol
CNP
NCBI Official Synonym Symbols
CNP1
UniProt Protein Name
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Protein Family
2',3'-cyclic-nucleotide 3'-phosphodiesterase
UniProt Gene Name
CNP
UniProt Synonym Gene Names
CNP; CNPase
NCBI Protein Information
2',3'-cyclic-nucleotide 3'-phosphodiesterase

UniProt Comments for CNP

CNP: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. Exists as monomers and homodimers. Belongs to the cyclic nucleotide phosphodiesterase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; EC 3.1.4.37; Phosphodiesterase

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cytoplasm; extracellular exosome; extracellular space; melanosome; membrane; microvillus; mitochondrial inner membrane; mitochondrial outer membrane; perinuclear region of cytoplasm; plasma membrane; pseudopodium

Molecular Function: 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity; cyclic nucleotide binding; RNA binding

Biological Process: adult locomotory behavior; aging; axonogenesis; cyclic nucleotide catabolic process; forebrain development; microtubule cytoskeleton organization; oligodendrocyte differentiation; regulation of mitochondrial membrane permeability; response to lipopolysaccharide; response to toxin; substantia nigra development; synaptic transmission
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Research Articles on CNP

1. This study showed that the expression of CNPase protein was significantly decreased but increase expression mrna in ventral prefrontal white matter in major depressive disorder.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CNP antibody

 Reference Product  PubMed Publications
 MBP antibody  >148 publications with CNP and MBP
 MAG antibody  >62 publications with CNP and MAG
 GFAP antibody  >56 publications with CNP and GFAP
 NPPC antibody  >32 publications with CNP and NPPC
 PLP1 antibody  >20 publications with CNP and PLP1
 STAT5B antibody  >1 publications with CNP and STAT5B

Pathways associated with anti-CNP antibody

 Products by Pathway  Pathway Diagram
 Glial Cell Differentiation Pathway antibodies  Glial Cell Differentiation Pathway Diagram
 MECP2 And Associated Rett Syndrome Pathway antibodies  MECP2 And Associated Rett Syndrome Pathway Diagram

Diseases associated with anti-CNP antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >284 publications with CNP and Nervous System Diseases
 Brain Diseases Antibodies  >219 publications with CNP and Brain Diseases
 Hypertension Antibodies  >127 publications with CNP and Hypertension
 Disease Models, Animal Antibodies  >117 publications with CNP and Disease Models, Animal
 Inflammation Antibodies  >101 publications with CNP and Inflammation
 Immune System Diseases Antibodies  >77 publications with CNP and Immune System Diseases
 Kidney Diseases Antibodies  >62 publications with CNP and Kidney Diseases
 Fibrosis Antibodies  >51 publications with CNP and Fibrosis
 Necrosis Antibodies  >49 publications with CNP and Necrosis
 Hypertrophy Antibodies  >48 publications with CNP and Hypertrophy

Organs/Tissues associated with anti-CNP antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >970 publications with CNP and Brain
 Blood Antibodies  >599 publications with CNP and Blood
 Nerve Antibodies  >402 publications with CNP and Nerve
 Vascular Antibodies  >386 publications with CNP and Vascular
 Heart Antibodies  >366 publications with CNP and Heart
 Muscle Antibodies  >339 publications with CNP and Muscle
 Kidney Antibodies  >200 publications with CNP and Kidney
 Bone Antibodies  >147 publications with CNP and Bone
 Spinal Cord Antibodies  >137 publications with CNP and Spinal Cord
 Lung Antibodies  >107 publications with CNP and Lung
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