3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

BNP Recombinant Protein

Name: BNP Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203219
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203219

BNP (Brain natriuretic peptide) is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. BNP is a 32 amino acid polypeptide and is co-secreted along with a 76 amino acid N-terminal fragment which is… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BNP, Recombinant Protein

Full Product Name

BNP, 27-134aa, Human, His tag, E Coli

Product Gene Name

BNP recombinant protein

Product Synonym Names

Brain natriuretic peptide (type B natriuretic peptide); NPPB; GC-B; Brain natriuretic peptide (type B natriuretic peptide); BNP; Brain natriuretic peptide (type B natriuretic peptide) Gamma brain natriuretic peptide; Natriuretic peptide precursor B; Natriuretic peptides B

Sequence

MGSSHHHHHH SSGLVPRGSH MHPLGSPGSA SDLETSGLQE QRNHLQGKLS ELQVEQTSLE PLQESPRPTG VWKSREVATE GIRGHRKMVL YTLRAPRSPK MVQGSGCFGR KMDRISSSSG LGCKVLRRH

Host

E Coli

Form/Format

Liquid In phosphate-buffered saline (pH 7.4), 40%glycerol, 2mM DTT, 0.1mM PMSF, 1mM EDTA

Purity/Purification

> 85% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at +2°C to +8°C for 1 week.
For long term storage, aliquot and store at -20°C or -80°C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

14 kDa (129 aa), confirmed by MALDI-TOF.

OMIM

M31776 Genomic DNA

3D Structure

ModBase 3D Structure for P16860

Antigen Species

Human

Tag Information

His-tag

Endotoxin Level

< 1.0 EU per 1 microgram of protein (determined by LAL method)

Domain

27-134aa

Product Categories/Family for BNP recombinant protein

Hormones & Cytokines

Applications Tested/Suitable for BNP recombinant protein

SDS-PAGE

Product References and Citations for BNP recombinant protein

Harada H., et al. (1989) Cell. 58 (4):729-739 ; Matsuyama T., et al. (1993) Cell 75 (1):83-97;

Other Notes

Small volumes of BNP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BNP purchase

MBS203219 is a recombinant protein targeting BNP. Also known as BNP, 27-134aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BNP. It may not necessarily be applicable to this product.

NCBI GI #

4505433

NCBI GeneID

4879

NCBI Accession #

NP_002512

UniProt Primary Accession #

P16860

UniProt Secondary Accession #

Q6FGY0; Q9P2Q7; B0ZBE9

UniProt Related Accession #

P16860

GenBank Nucleotide #

NM_002521.2

NCBI Official Full Name

natriuretic peptides B preproprotein

NCBI Official Synonym Full Names

natriuretic peptide B

NCBI Official Symbol

NPPB

NCBI Official Synonym Symbols

BNP

UniProt Protein Name

Natriuretic peptides B

UniProt Synonym Protein Names

Gamma-brain natriuretic peptide

UniProt Gene Name

NPPB

UniProt Synonym Gene Names

BNP(1-32); BNP-32

NCBI Protein Information

natriuretic peptides B

NCBI Summary for BNP

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]

UniProt Comments for BNP

Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Research Articles on BNP

1. Higher blood levels of NT-proBNP was associated with incident cognitive impairments.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BNP recombinant protein

Reference Product	PubMed Publications
NPPA recombinant protein	>69 publications with BNP and NPPA
NPPC recombinant protein	>10 publications with BNP and NPPC
NPR3 recombinant protein	>10 publications with BNP and NPR3
NPR1 recombinant protein	>9 publications with BNP and NPR1
NPR2 recombinant protein	>7 publications with BNP and NPR2
ACE recombinant protein	>3 publications with BNP and ACE
TNNI3 recombinant protein	>2 publications with BNP and TNNI3
ATF2 recombinant protein	>1 publications with BNP and ATF2

Pathways associated with BNP recombinant protein

Products by Pathway	Pathway Diagram
MicroRNAs In Cardiomyocyte Hypertrophy Pathway antibodies	MicroRNAs In Cardiomyocyte Hypertrophy Pathway Diagram
CGMP-PKG Signaling Pathway antibodies	CGMP-PKG Signaling Pathway Diagram
CGMP-PKG Signaling Pathway antibodies	CGMP-PKG Signaling Pathway Diagram

Diseases associated with BNP recombinant protein

Disease Name	Pubmed Publications
Fibrosis Antibodies	>153 publications with BNP and Fibrosis
Cardiovascular Diseases Antibodies	>103 publications with BNP and Cardiovascular Diseases
Heart Diseases Antibodies	>61 publications with BNP and Heart Diseases
Heart Failure Antibodies	>39 publications with BNP and Heart Failure
Hypertension Antibodies	>35 publications with BNP and Hypertension
Hypertrophy Antibodies	>34 publications with BNP and Hypertrophy
Cardiomegaly Antibodies	>20 publications with BNP and Cardiomegaly
Edema Antibodies	>19 publications with BNP and Edema
Cardiomyopathies Antibodies	>18 publications with BNP and Cardiomyopathies
Inflammation Antibodies	>17 publications with BNP and Inflammation

Organs/Tissues associated with BNP recombinant protein

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>151 publications with BNP and Kidney
Heart Antibodies	>125 publications with BNP and Heart
Lung Antibodies	>69 publications with BNP and Lung
Liver Antibodies	>44 publications with BNP and Liver
Pancreas Antibodies	>29 publications with BNP and Pancreas
Embryonic Tissue Antibodies	>23 publications with BNP and Embryonic Tissue