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CXCL3/GRO Gamma (CXCL3) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203225

CXCL3/GROg is a small cytokine belonging to the CXC chemokine family. CXCL3 controls migration and adhesion of monocytes and mediates it effects on its target cell by interacting with a cell surface chemokine receptor called CXCR2. Recombinant human CXCL3… More details

$230 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CXCL3/GRO gamma, Recombinant Protein
Full Product Name
CXCL3/GRO gamma, 35-107aa, Human, His tag, E Coli
Product Gene Name
CXCL3 recombinant protein
Product Synonym Names
Chemokine (C-X-C motif) ligand 3; Chemokine (C-X-C motif) ligand 3; CINC-2b; GRO3; GROg; MIP2B; SCYB3; CXCL3/GRO gamma; Chemokine (C-X-C motif) ligand 3 Chemokine (CXC motif) ligand 3; Cinc 2; Cinc2; CINC2b; CXCL 3; CXCL3; Cytokine induced neutrophil chemoattractant 2; Dcip1; GRO3 oncogene; Dendritic cell inflammatory protein 1; Gm1960; GROG; Growth regulated protein gamma; Macrophage inflammatory protein 2 beta precursor; Melanoma growth stimulatory activity gamma; MGSA gamma; MIP 2b; MIP2B; SCYB3.
Sequence
MGSSHHHHHH SSGLVPRGSH MASVVTELRC QCLQTLQGIH LKNIQSVNVR SPGPHCAQTE VIATLKNGKK ACLNPASPMV QKIIEKILNK GSTN
Host
E Coli
Form/Format
Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 20% glycerol
Purity/Purification
> 95% by SDS-PAGE
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
10.1kDa (94aa), confirmed by MALDI-TOF.
OMIM
X53800 mRNA
3D Structure
ModBase 3D Structure for P19876
Antigen Species
Human
Tag Information
His-tag
Endotoxin Level
< 1.0 EU per 1 microgram of protein (determined by LAL method)

Product Categories/Family for CXCL3 recombinant protein

Hormones & Cytokines
Applications Tested/Suitable for CXCL3 recombinant protein
SDS-PAGE

SDS-Page of CXCL3 recombinant protein

CXCL3 Recombinant Protein – Cat# MBS203225

Product References and Citations for CXCL3 recombinant protein

Bieche I., et al. (2007). Endocr Relat Canter. 14 (4):1039-52; Rainard P., et al. (2008). Mol Immunol. 45 (15):4020-7; Furuichi., et al. (2008). Front biosci. 13:4021-8;

Other Notes

Small volumes of CXCL3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCL3 purchase

MBS203225 is a recombinant protein targeting CXCL3. Also known as CXCL3/GRO gamma, 35-107aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCL3. It may not necessarily be applicable to this product.

NCBI GI #
54144650
NCBI GeneID
2921
NCBI Accession #
NP_002081
UniProt Primary Accession #
P19876
UniProt Secondary Accession #
Q4W5H9
UniProt Related Accession #
P19876
GenBank Nucleotide #
NM_002090.2
NCBI Official Full Name
C-X-C motif chemokine 3
NCBI Official Synonym Full Names
C-X-C motif chemokine ligand 3
NCBI Official Symbol
CXCL3
NCBI Official Synonym Symbols
GRO3; GROg; MIP2B; SCYB3; MIP-2b; CINC-2b
UniProt Protein Name
C-X-C motif chemokine 3
UniProt Synonym Protein Names
GRO-gamma(1-73); Growth-regulated protein gamma; GRO-gamma
Protein Family
C-X-C motif chemokine
UniProt Gene Name
CXCL3
UniProt Synonym Gene Names
GRO3; GROG; SCYB3; GRO-gamma; MIP2-beta
NCBI Protein Information
C-X-C motif chemokine 3

NCBI Summary for CXCL3

This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]
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UniProt Comments for CXCL3

Ligand for CXCR2 (). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.

Research Articles on CXCL3

1. Our findings suggest that CXCL3 and its receptor CXCR2 are overexpressed in prostate cancer cells, prostate epithelial cells and prostate cancer tissues, which may play multiple roles in prostate cancer progression and metastasis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CXCL3 recombinant protein

 Reference Product  PubMed Publications
 CXCL2 recombinant protein  >125 publications with CXCL3 and CXCL2
 CCL20 recombinant protein  >48 publications with CXCL3 and CCL20
 CCL5 recombinant protein  >32 publications with CXCL3 and CCL5
 CXCL10 recombinant protein  >30 publications with CXCL3 and CXCL10
 CXCR2 recombinant protein  >19 publications with CXCL3 and CXCR2
 CXCL11 recombinant protein  >16 publications with CXCL3 and CXCL11
 CXCR1 recombinant protein  >10 publications with CXCL3 and CXCR1
 CXCL12 recombinant protein  >9 publications with CXCL3 and CXCL12
 CCL19 recombinant protein  >6 publications with CXCL3 and CCL19

Pathways associated with CXCL3 recombinant protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 IL-17 Signaling Pathway antibodies  IL-17 Signaling Pathway Diagram

Diseases associated with CXCL3 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >107 publications with CXCL3 and Inflammation
 Necrosis Antibodies  >43 publications with CXCL3 and Necrosis
 Lung Diseases Antibodies  >17 publications with CXCL3 and Lung Diseases
 Disease Models, Animal Antibodies  >13 publications with CXCL3 and Disease Models, Animal
 Skin Diseases Antibodies  >13 publications with CXCL3 and Skin Diseases
 Death Antibodies  >11 publications with CXCL3 and Death
 Fibrosis Antibodies  >8 publications with CXCL3 and Fibrosis
 Neoplasms, Experimental Antibodies  >7 publications with CXCL3 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >6 publications with CXCL3 and Lung Neoplasms
 Heart Diseases Antibodies  >6 publications with CXCL3 and Heart Diseases

Organs/Tissues associated with CXCL3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >84 publications with CXCL3 and Blood
 Lung Antibodies  >25 publications with CXCL3 and Lung
 Intestine Antibodies  >15 publications with CXCL3 and Intestine
 Brain Antibodies  >13 publications with CXCL3 and Brain
 Liver Antibodies  >8 publications with CXCL3 and Liver
 Embryonic Tissue Antibodies  >5 publications with CXCL3 and Embryonic Tissue
 Uterus Antibodies  >4 publications with CXCL3 and Uterus
 Uncharacterized Tissue Antibodies  >1 publications with CXCL3 and Uncharacterized Tissue
 Pancreas Antibodies  >1 publications with CXCL3 and Pancreas
 Bladder Antibodies  >1 publications with CXCL3 and Bladder
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