BMP-4 Recombinant Protein – Cat# MBS203228

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain

BMP- 4 (BMP-4) Recombinant Protein

Name: BMP-4 Recombinant Protein; BMP- 4; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203228
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203228

Bone morphogenetic protein 4 (BMP-4) is a member of the bone morphogenetic protein family which belongs to the TGF-beta superfamily. This protein is a vital regulatory molecule that functions throughout bone and cartilage development, specifically tooth… More details

$210 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BMP- 4 (BMP-4), Recombinant Protein

Full Product Name

BMP- 4 (monomer), 293-408aa, Human, E Coli

Product Gene Name

BMP-4 recombinant protein

Product Synonym Names

Bone morphogenetic protein 4; BMP-2B; DVR4; Bone morphogenetic protein 4 BMP 4; BMP2B; BMP2B1; ZYME; BMP4

Sequence

MSPKHHSQRA RKKNKNCRRH SLYVDFSDVG WNDWIVAPPG YQAFYCHGDC PFPLADHLNS TNHAIVQTLV NSVNSSIPKA CCVPTELSAI SMLYLDEYDK VVLKNYQEMV VEGCGCR

Host

E Coli

Form/Format

Liquid. In 10mM Sodium citrate buffer (pH 3.5), 10% glycerol

Purity/Purification

> 85% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 2 degree C to 8 degree C for one week.
For long term storage, aliquot and store at -20 degree C to -80 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

13.2 kDa (117 aa), confirmed by MALDI-TOF.

OMIM

M22490 mRNA

3D Structure

ModBase 3D Structure for P12644

Domain

293-408aa

Tag

Non-tagged

Endotoxin Level

< 1.0 EU per 1ug of protein (determined by LAL method)

Product Categories/Family for BMP-4 recombinant protein

Hormones & Cytokines

Applications Tested/Suitable for BMP-4 recombinant protein

SDS-PAGE

Product References and Citations for BMP-4 recombinant protein

Moon BS., et al. (2009) Exp Mol Med. 41 (2):116-25.; Li BC., et al. (2009) J Trauma. 66 (2):450-6;

Other Notes

Small volumes of BMP-4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMP-4 purchase

MBS203228 is a recombinant protein targeting BMP-4. Also known as BMP- 4 (monomer), 293-408aa, Human, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BMP-4. It may not necessarily be applicable to this product.

NCBI GI #

157276593

NCBI GeneID

652

NCBI Accession #

NP_001193

UniProt Primary Accession #

P12644

UniProt Secondary Accession #

Q9UM80

UniProt Related Accession #

P12644

GenBank Nucleotide #

NM_001202.5

NCBI Official Full Name

bone morphogenetic protein 4 isoform a preproprotein

NCBI Official Synonym Full Names

bone morphogenetic protein 4

NCBI Official Symbol

BMP4

NCBI Official Synonym Symbols

ZYME; BMP2B; OFC11; BMP2B1; MCOPS6

UniProt Protein Name

Bone morphogenetic protein 4

UniProt Synonym Protein Names

Bone morphogenetic protein 2B; BMP-2B

Protein Family

Bone morphogenetic protein receptor

UniProt Gene Name

BMP4

UniProt Synonym Gene Names

BMP2B; DVR4; BMP-4; BMP-2B

NCBI Protein Information

bone morphogenetic protein 4

NCBI Summary for BMP-4

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]

UniProt Comments for BMP-4

Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction ().

Research Articles on BMP-4

1. BMP4 expression was significantly increased in HCC tissue, and was correlated with tumor de-differentiation and unfavorable prognosis. BMP4 promoted HCC EMT and was correlated with OXA resistance.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BMP-4 recombinant protein

Reference Product	PubMed Publications
BMPR2 recombinant protein	>184 publications with BMP-4 and BMPR2
SMAD5 recombinant protein	>102 publications with BMP-4 and SMAD5
BMPR1A recombinant protein	>98 publications with BMP-4 and BMPR1A
BMPR1B recombinant protein	>54 publications with BMP-4 and BMPR1B
GREM1 recombinant protein	>46 publications with BMP-4 and GREM1
ACVR1 recombinant protein	>31 publications with BMP-4 and ACVR1
NOG recombinant protein	>25 publications with BMP-4 and NOG
SMAD9 recombinant protein	>15 publications with BMP-4 and SMAD9
FST recombinant protein	>8 publications with BMP-4 and FST
CHRD recombinant protein	>6 publications with BMP-4 and CHRD

Pathways associated with BMP-4 recombinant protein

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
BMP Signaling Pathway antibodies	BMP Signaling Pathway Diagram
BMP Signaling Pathway antibodies	BMP Signaling Pathway Diagram
Basal Cell Carcinoma Pathway antibodies	Basal Cell Carcinoma Pathway Diagram
Basal Cell Carcinoma Pathway antibodies	Basal Cell Carcinoma Pathway Diagram
Cardiac Progenitor Differentiation Pathway antibodies	Cardiac Progenitor Differentiation Pathway Diagram
Differentiation Pathway antibodies	Differentiation Pathway Diagram
Differentiation Of White And Brown Adipocyte Pathway antibodies	Differentiation Of White And Brown Adipocyte Pathway Diagram
Ectoderm Differentiation Pathway antibodies	Ectoderm Differentiation Pathway Diagram
Elastic Fibre Formation Pathway antibodies	Elastic Fibre Formation Pathway Diagram

Diseases associated with BMP-4 recombinant protein

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>149 publications with BMP-4 and Disease Models, Animal
Cardiovascular Diseases Antibodies	>148 publications with BMP-4 and Cardiovascular Diseases
Nervous System Diseases Antibodies	>141 publications with BMP-4 and Nervous System Diseases
Heart Diseases Antibodies	>86 publications with BMP-4 and Heart Diseases
Inflammation Antibodies	>86 publications with BMP-4 and Inflammation
Hypertension Antibodies	>81 publications with BMP-4 and Hypertension
Lung Diseases Antibodies	>70 publications with BMP-4 and Lung Diseases
Necrosis Antibodies	>57 publications with BMP-4 and Necrosis
Fibrosis Antibodies	>48 publications with BMP-4 and Fibrosis
Kidney Diseases Antibodies	>44 publications with BMP-4 and Kidney Diseases

Organs/Tissues associated with BMP-4 recombinant protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>3217 publications with BMP-4 and Bone
Embryonic Tissue Antibodies	>779 publications with BMP-4 and Embryonic Tissue
Brain Antibodies	>332 publications with BMP-4 and Brain
Vascular Antibodies	>324 publications with BMP-4 and Vascular
Heart Antibodies	>293 publications with BMP-4 and Heart
Connective Tissue Antibodies	>233 publications with BMP-4 and Connective Tissue
Mouth Antibodies	>214 publications with BMP-4 and Mouth
Eye Antibodies	>200 publications with BMP-4 and Eye
Lung Antibodies	>169 publications with BMP-4 and Lung
Skin Antibodies	>148 publications with BMP-4 and Skin