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FADD Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203238

FADD (Fas-associated protein with death domain) is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. This protein is implicated in survival/proliferation and cell cycle progression. FADD functions are… More details

$230 / 0.02 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FADD, Recombinant Protein
Full Product Name
FADD,1-208aa, Human GST-tag, E Coli
Product Gene Name
FADD recombinant protein
Product Synonym Names
Fas-associated via death domain; GIG3; MORT1; MGC8528; Fas-associated via death domain; FADD; Fas-associated via death domain FADD protein; Fas TNFRSF6 associated via death domain; Fas (TNFRSF6) associated via death domain; Fas associated via death domain; Fas associating protein; Fas associating death domain containing protein; Fas associating protein with death domain GIG 3; Growth inhibiting gene 3 protein; H sapiens mRNA for mediator of receptor induced toxicity; Mediator of receptor induced toxicity; MORT 1.
Sequence
MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD LVPRGSMDPF LVLLHSVSSS LSSSELTELK FLCLGRVGKR KLERVQSGLD LFSMLLEQND LEPGHTELLR ELLASLRRHD LLRRVDDFEA GAAAGAAPGE EDLCAAFNVI CDNVGKDWRR LARQLKVSDT KIDSIEDRYP RNLTERVRES LRIWKNTEKE NATVAHLVGA LRSCQMNLVA DLVQEVQQAR DLQNRSGAMS PMSWNSDAST SEAS
Host
E Coli
Form/Format
Liquid In phosphate-buffered saline (PBS), 20% glycerol
Purity/Purification
> 95% by SDS-PAGE
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
49kDa (434aa), confirmed by MALDI-TOF.
OMIM
U24231 mRNA
3D Structure
ModBase 3D Structure for Q13158
Antigen Species
Human
Tag Information
GST tag

Product Categories/Family for FADD recombinant protein

Cancer
Applications Tested/Suitable for FADD recombinant protein
SDS-PAGE

SDS-Page of FADD recombinant protein

FADD Recombinant Protein – Cat# MBS203238

Product References and Citations for FADD recombinant protein

Lea Tourneur.,et al: (2005) Medical Immunology. 4:1; Tsao,C.H., et al: (2008) J. Gen. Virol. 89; (PT 8), 1930-1941;

Other Notes

Small volumes of FADD recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FADD purchase

MBS203238 is a recombinant protein targeting FADD. Also known as FADD,1-208aa, Human GST-tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FADD. It may not necessarily be applicable to this product.

NCBI GI #
4505229
NCBI GeneID
8772
NCBI Accession #
NP_003815
UniProt Primary Accession #
Q13158
UniProt Secondary Accession #
Q14866; Q6IBR4
UniProt Related Accession #
Q13158
GenBank Nucleotide #
NM_003824.3
NCBI Official Full Name
FAS-associated death domain protein
NCBI Official Synonym Full Names
Fas associated via death domain
NCBI Official Symbol
FADD
NCBI Official Synonym Symbols
GIG3; MORT1
UniProt Protein Name
FAS-associated death domain protein
UniProt Synonym Protein Names
FAS-associating death domain-containing protein; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; Protein FADD
Protein Family
Fas-associated death domain protein
UniProt Gene Name
FADD
UniProt Synonym Gene Names
MORT1
NCBI Protein Information
FAS-associated death domain protein

NCBI Summary for FADD

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
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UniProt Comments for FADD

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
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Research Articles on FADD

1. FADD expression and its phosphorylation can be reliable biomarkers with prognostic value for T-cell lymphoblastic lymphoma stratification.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FADD recombinant protein

 Reference Product  PubMed Publications
 CASP8 recombinant protein  >2424 publications with FADD and CASP8
 FAS recombinant protein  >2196 publications with FADD and FAS
 CFLAR recombinant protein  >932 publications with FADD and CFLAR
 TNFSF10 recombinant protein  >399 publications with FADD and TNFSF10
 TRADD recombinant protein  >246 publications with FADD and TRADD
 FASLG recombinant protein  >209 publications with FADD and FASLG
 TNFRSF10A recombinant protein  >110 publications with FADD and TNFRSF10A
 TNFRSF10B recombinant protein  >109 publications with FADD and TNFRSF10B
 CASP10 recombinant protein  >48 publications with FADD and CASP10
 TNFRSF1A recombinant protein  >22 publications with FADD and TNFRSF1A

Pathways associated with FADD recombinant protein

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 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis - Multiple Species Pathway antibodies  Apoptosis - Multiple Species Pathway Diagram
 Apoptosis - Multiple Species Pathway antibodies  Apoptosis - Multiple Species Pathway Diagram

Diseases associated with FADD recombinant protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1357 publications with FADD and Necrosis
 Inflammation Antibodies  >227 publications with FADD and Inflammation
 Disease Models, Animal Antibodies  >133 publications with FADD and Disease Models, Animal
 Liver Diseases Antibodies  >122 publications with FADD and Liver Diseases
 Cardiovascular Diseases Antibodies  >116 publications with FADD and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >116 publications with FADD and Breast Neoplasms
 Lung Neoplasms Antibodies  >93 publications with FADD and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >80 publications with FADD and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >78 publications with FADD and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >72 publications with FADD and Neoplasms, Experimental

Organs/Tissues associated with FADD recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >626 publications with FADD and Blood
 Liver Antibodies  >193 publications with FADD and Liver
 Lung Antibodies  >165 publications with FADD and Lung
 Brain Antibodies  >163 publications with FADD and Brain
 Prostate Antibodies  >123 publications with FADD and Prostate
 Muscle Antibodies  >109 publications with FADD and Muscle
 Vascular Antibodies  >99 publications with FADD and Vascular
 Kidney Antibodies  >97 publications with FADD and Kidney
 Heart Antibodies  >91 publications with FADD and Heart
 Skin Antibodies  >87 publications with FADD and Skin
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