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Ureidopropionase Beta (UPb1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2032439
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MBS2032439 is an antibody targeting UPb1. Also known as Ureidopropionase Beta (UPb1) Polyclonal Antibody. Reactive in Human, Rat, Pig. Host: Rabbit. More details

$215 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Ureidopropionase Beta (UPb1), Polyclonal Antibody
Full Product Name
Ureidopropionase Beta (UPb1) Polyclonal Antibody
Product Gene Name
anti-UPb1 antibody
Product Synonym Names
UP-B1; BUP1; Beta-alanine synthase; N-carbamoyl-beta-alanine amidohydrolase
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Rat, Pig
Form/Format
Supplied as solution form in PBS, pH7.4 containing 0.02% NaN3, 50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against UPb1. It has been selected for its ability to recognize UPb1 in immunohistochemical staining and western blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: UPb1 (MBS2032439)
Immunogen: UPb1 (MBS2033031)
Matching Pairs
Unconjugated Antibody: UPb1 (MBS2032439)
APC-CY7 Conjugated Antibody: UPb1 (MBS2066899)
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Molecular Weight
43,166 Da
OMIM
AF163312 mRNA
3D Structure
ModBase 3D Structure for Q9UBR1
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunoglobulin Type
IgG
Conjugate
No Conjugate
Cross Reactivity
Human, Rat, Pig
Organism Species
Human
Fragment
UPb1 (Trp121~Glu384)
Quality Control
Content: The quality control contains recombinant UPb1 (Trp121~Glu384) disposed in loading buffer.
Usage: 10uL per well when 3,3'-Diaminobenzidine(DAB) as the substrate.
5uL per well when used in enhanced chemilumescent (ECL).
Note: The quality control is specifically manufactured as the positive control.Not used for other purposes.
Loading Buffer: 100mM Tris(pH8.8), 2% SDS, 200mM NaCl, 50% glycerol,BPB 0.01%, NaN3 0.02%.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2066901
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-UPb1 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
Application Notes for anti-UPb1 antibody
Western Blot: 1:50-400
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-UPb1 antibody

Western Blot: Sample: Lane1: Porcine Liver Tissue; Lane2: Rat Liver Tissue.
Rabbit Anti-UPb1 Polyclonal Antibody – Cat# MBS2032439

Western Blot (WB) of anti-UPb1 antibody

Western Blot: Sample: Recombinant UPb1, Human.
Rabbit Anti-UPb1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS2032439

Immunohistochemistry (IHC) of anti-UPb1 antibody

DAB staining on IHC-P; Samples: Human Liver Tissue.
Rabbit Anti-UPb1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2032439

Immunohistochemistry (IHC) of anti-UPb1 antibody

DAB staining on IHC-P; Samples: Human Kidney Tissue
Rabbit Anti-UPb1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2032439

Immunohistochemistry (IHC) of anti-UPb1 antibody

DAB staining on IHC-P; Samples: Human Liver Cancer Tissue.
Rabbit Anti-UPb1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2032439

Other Notes

Small volumes of anti-UPb1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for UPb1. It may not necessarily be applicable to this product.

NCBI GI #
7706509
NCBI GeneID
51733
NCBI Accession #
NP_057411.1
UniProt Primary Accession #
Q9UBR1
UniProt Secondary Accession #
Q9UIR3; A3KMF8
UniProt Related Accession #
Q9UBR1
GenBank Nucleotide #
NM_016327.2
NCBI Official Full Name
beta-ureidopropionase
NCBI Official Synonym Full Names
beta-ureidopropionase 1
NCBI Official Symbol
UPB1
NCBI Official Synonym Symbols
BUP1
UniProt Protein Name
Beta-ureidopropionase
UniProt Synonym Protein Names
BUP-1; Beta-alanine synthase; N-carbamoyl-beta-alanine amidohydrolase
Protein Family
Transcription factor
UniProt Gene Name
UPB1
UniProt Synonym Gene Names
BUP1
NCBI Protein Information
beta-ureidopropionase

NCBI Summary for UPb1

This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity. [provided by RefSeq, Jul 2008]
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UniProt Comments for UPb1

UPB1: Converts N-carbamyl-beta-aminoisobutyric acid and N- carbamyl-beta-alanine to, respectively, beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide. Defects in UPB1 are the cause of beta-ureidopropionase deficiency (BUPD). It is characterized by muscular hypotonia, dystonic movements, scoliosis, microcephaly and severe developmental delay. Patients show strongly elevated levels of N- carbamyl-beta-alanine and N-carbamyl-beta-aminoisobutyric acid in plasma, cerebrospinal fluid and urine. Belongs to the CN hydrolase family. BUP subfamily.

Protein type: Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 3.5.1.6; Hydrolase; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - beta-alanine; Xenobiotic Metabolism - drug metabolism - other enzymes

Chromosomal Location of Human Ortholog: 22q11.23

Cellular Component: cytosol

Molecular Function: beta-ureidopropionase activity; metal ion binding

Biological Process: beta-alanine biosynthetic process; pyrimidine nucleoside catabolic process

Disease: Beta-ureidopropionase Deficiency
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Research Articles on UPb1

1. The c.977G>A (p.R326Q) is the most common mutation of the UPB1 gene in Chinese. The predicted incidence indicates that beta-ureidopropionase deficiency is significantly underdiagnosed in the Chinese population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UPb1 antibody

 Reference Product  PubMed Publications
 DPYS antibody  >3 publications with UPb1 and DPYS
 DPYD antibody  >2 publications with UPb1 and DPYD

Pathways associated with anti-UPb1 antibody

 Products by Pathway  Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Pantothenate And CoA Biosynthesis Pathway antibodies  Pantothenate And CoA Biosynthesis Pathway Diagram
 Pantothenate And CoA Biosynthesis Pathway antibodies  Pantothenate And CoA Biosynthesis Pathway Diagram
 Pyrimidine Catabolism Pathway antibodies  Pyrimidine Catabolism Pathway Diagram
 Pyrimidine Degradation, Uracil => Beta-alanine, Thymine => 3-aminoisobutanoate Pathway antibodies  Pyrimidine Degradation, Uracil => Beta-alanine, Thymine => 3-aminoisobutanoate Pathway Diagram

Diseases associated with anti-UPb1 antibody

 Disease Name  Pubmed Publications
 Beta-Ureidopropionase Deficiency Antibodies  >9 publications with UPb1 and Beta-Ureidopropionase Deficiency
 Metabolic Diseases Antibodies  >6 publications with UPb1 and Metabolic Diseases
 Congenital Abnormalities Antibodies  >4 publications with UPb1 and Congenital Abnormalities
 Brain Diseases Antibodies  >3 publications with UPb1 and Brain Diseases
 Seizures Antibodies  >3 publications with UPb1 and Seizures
 Mental Disorders Antibodies  >1 publications with UPb1 and Mental Disorders
 Liver Diseases Antibodies  >1 publications with UPb1 and Liver Diseases

Organs/Tissues associated with anti-UPb1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with UPb1 and Brain
 Liver Antibodies  >1 publications with UPb1 and Liver
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