BCL-2 Recombinant Protein

Name: BCL-2 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203249
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203249

Bcl-2, also known as B-cell lymphoma protein 2 alpha, is an anti-apoptotic protein located primarily in the outer mitochondrial membrane that blocks the apoptotic death of some cells such as lymphocytes. BCL-2 is thought to regulate cell death by controlling… More details

$245 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Bcl-2, Recombinant Protein

Full Product Name

Bcl-2, 1-211aa, Human, His tag, E Coli

Product Gene Name

Bcl-2 recombinant protein

Product Synonym Names

B-cell lymphoma protein 2 alpha; B-cell lymphoma protein 2 alpha; B-cell lymphoma protein 2 alpha Apoptosis regulator Bcl 2; Apoptosis regulator Bcl2; AW986256; B cell CLL/lymphoma 2; B cell leukemia/lymphoma 2; Bcl-2; Bcl2; C430015F12Rik; D630044D05Rik; D830018M01Rik; Leukemia/lymphoma; B-cell; 2; Oncogene B-cell leukemia 2.

Sequence

MGSSHHHHHH SSGLVPRGSH MAHAGRTGYD NREIVMKYIH YKLSQRGYEW DAGDVGAAPP GAAPAPGIFS SQPGHTPHPA ASRDPVARTS PLQTPAAPGA AAGPALSPVP PVVHLTLRQA GDDFSRRYRR DFAEMSSQLH LTPFTARGRF ATVVEELFRD GVNWGRIVAF FEFGGVMCVE SVNREMSPLV DNIALWMTEY LNRHLHTWIQ DNGGWDAFVE LYGPSMRPLF D

Host

E Coli

Form/Format

Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol 2 mM DTT

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.25 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

25.4 kDa (231 aa), confirmed by MALDI-TOF.

OMIM

M13994 mRNA

3D Structure

ModBase 3D Structure for P10415

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for Bcl-2 recombinant protein

Cancer

Applications Tested/Suitable for Bcl-2 recombinant protein

SDS-PAGE

Product References and Citations for Bcl-2 recombinant protein

Zamzami N., et al. (1998) Oncogene. 16 (17):2265-82.; Fernandez-Sarabia MJ., et al. (1993) Nature. 366 (6452):274-5.;

Other Notes

Small volumes of Bcl-2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Bcl-2 purchase

MBS203249 is a recombinant protein targeting Bcl-2. Also known as Bcl-2, 1-211aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Bcl-2. It may not necessarily be applicable to this product.

NCBI GI #

72198189

NCBI GeneID

596

NCBI Accession #

NP_000624

UniProt Primary Accession #

P10415

UniProt Secondary Accession #

P10416; Q13842; Q16197; C9JHD5

UniProt Related Accession #

P10415

GenBank Nucleotide #

NM_000633.2

NCBI Official Full Name

apoptosis regulator Bcl-2 alpha isoform

NCBI Official Synonym Full Names

BCL2, apoptosis regulator

NCBI Official Symbol

BCL2

NCBI Official Synonym Symbols

Bcl-2; PPP1R50

UniProt Protein Name

Apoptosis regulator Bcl-2

Protein Family

Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein

UniProt Gene Name

BCL2

NCBI Protein Information

apoptosis regulator Bcl-2

NCBI Summary for Bcl-2

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

UniProt Comments for Bcl-2

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).

Research Articles on Bcl-2

1. The BAK1/BCL2 ratio was positively correlated with the results of audiometric tests. Our results indicate that BAK-mediated apoptosis may be a core mechanism in the progression of age-related hearing impairment in humans

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Bcl-2 recombinant protein

Reference Product	PubMed Publications
MYC recombinant protein	>792 publications with Bcl-2 and MYC
TP53 recombinant protein	>282 publications with Bcl-2 and TP53
BCL2L11 recombinant protein	>118 publications with Bcl-2 and BCL2L11
APAF1 recombinant protein	>62 publications with Bcl-2 and APAF1
AKT1 recombinant protein	>60 publications with Bcl-2 and AKT1
PMAIP1 recombinant protein	>47 publications with Bcl-2 and PMAIP1
BBC3 recombinant protein	>37 publications with Bcl-2 and BBC3
MAPK1 recombinant protein	>22 publications with Bcl-2 and MAPK1
MAPK8 recombinant protein	>21 publications with Bcl-2 and MAPK8
CYCS recombinant protein	>9 publications with Bcl-2 and CYCS

Pathways associated with Bcl-2 recombinant protein

Products by Pathway	Pathway Diagram
AGE-RAGE Signaling Pathway In Diabetic Complications antibodies	AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
AGE-RAGE Signaling Pathway In Diabetic Complications antibodies	AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
ATF-2 Transcription Factor Network Pathway antibodies	ATF-2 Transcription Factor Network Pathway Diagram
Activation Of BAD And Translocation To Mitochondria Pathway antibodies	Activation Of BAD And Translocation To Mitochondria Pathway Diagram
Activation Of BH3-only Proteins Pathway antibodies	Activation Of BH3-only Proteins Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram

Diseases associated with Bcl-2 recombinant protein

Disease Name	Pubmed Publications
Carcinoma Antibodies	>1109 publications with Bcl-2 and Carcinoma
Lymphoma, Non-Hodgkin Antibodies	>1093 publications with Bcl-2 and Lymphoma, Non-Hodgkin
Lymphoma, Large B-Cell, Diffuse Antibodies	>606 publications with Bcl-2 and Lymphoma, Large B-Cell, Diffuse
Necrosis Antibodies	>601 publications with Bcl-2 and Necrosis
Lymphoma, Follicular Antibodies	>499 publications with Bcl-2 and Lymphoma, Follicular
Breast Neoplasms Antibodies	>487 publications with Bcl-2 and Breast Neoplasms
Adenocarcinoma Antibodies	>465 publications with Bcl-2 and Adenocarcinoma
Disease Progression Antibodies	>421 publications with Bcl-2 and Disease Progression
Intestinal Neoplasms Antibodies	>247 publications with Bcl-2 and Intestinal Neoplasms
Head and Neck Neoplasms Antibodies	>230 publications with Bcl-2 and Head and Neck Neoplasms

Organs/Tissues associated with Bcl-2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1546 publications with Bcl-2 and Blood
Brain Antibodies	>639 publications with Bcl-2 and Brain
Bone Antibodies	>547 publications with Bcl-2 and Bone
Muscle Antibodies	>492 publications with Bcl-2 and Muscle
Lung Antibodies	>483 publications with Bcl-2 and Lung
Vascular Antibodies	>403 publications with Bcl-2 and Vascular
Heart Antibodies	>402 publications with Bcl-2 and Heart
Bone Marrow Antibodies	>378 publications with Bcl-2 and Bone Marrow
Lymph Node Antibodies	>361 publications with Bcl-2 and Lymph Node
Lymph Antibodies	>294 publications with Bcl-2 and Lymph