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Myosin Heavy Chain 7b (MYH7B) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2032551
SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment

MBS2032551 is an antibody targeting MYH7B. Also known as Myosin Heavy Chain 7B, Cardiac Muscle Beta (MYH7B) Polyclonal Antibody. Reactive in Human, Pig. Host: Rabbit. More details

$225 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Myosin Heavy Chain 7B (MYH7B), Polyclonal Antibody
Full Product Name
Myosin Heavy Chain 7B, Cardiac Muscle Beta (MYH7B) Polyclonal Antibody
Product Gene Name
anti-MYH7B antibody
Product Synonym Names
MYH14; MHC14; Antigen MLAA-21; Myosin cardiac muscle beta chain
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Pig
Form/Format
Supplied as solution form in PBS, pH7.4 containing 0.02% NaN3, 50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against MYH7B. It has been selected for its ability to recognize MYH7B in immunohistochemical staining and western blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: MYH7B (MBS2032551)
Immunogen: MYH7B (MBS2033114)
Matching Pairs
Unconjugated Antibody: MYH7B (MBS2032551)
APC-CY7 Conjugated Antibody: MYH7B (MBS2084376)
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Molecular Weight
20,273 Da
OMIM
AY288964 mRNA
3D Structure
ModBase 3D Structure for A7E2Y1
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunoglobulin Type
IgG
Conjugate
No Conjugate
Cross Reactivity
Human
Organism Species
Human
Fragment
MYH7B (Asn829~Leu1106)
Quality Control
Content: The quality control contains recombinant MYH7B (Asn829~Leu1106) disposed in loading buffer.
Usage: 10uL per well when 3,3'-Diaminobenzidine(DAB) as the substrate.
5uL per well when used in enhanced chemilumescent (ECL).
Note: The quality control is specifically manufactured as the positive control.Not used for other purposes.
Loading Buffer: 100mM Tris(pH8.8), 2% SDS, 200mM NaCl, 50% glycerol,BPB 0.01%, NaN3 0.02%.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2084378
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-MYH7B antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
Application Notes for anti-MYH7B antibody
Western Blot: 1:50-400
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-MYH7B antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-MYH7B Polyclonal Antibody – Cat# MBS2032551

Immunohistochemistry (IHC) of anti-MYH7B antibody

DABstainingonIHC-P.Samples:HumanTissue)
Rabbit Anti-MYH7B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2032551

Other Notes

Small volumes of anti-MYH7B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MYH7B. It may not necessarily be applicable to this product.

NCBI GI #
599045671
NCBI GeneID
57644
NCBI Accession #
NP_065935.3
UniProt Primary Accession #
A7E2Y1
UniProt Secondary Accession #
Q5JVW7; Q6NT44; Q6NT57; Q6WG75; Q96I57; Q9NWE2; Q9P216
UniProt Related Accession #
A7E2Y1
GenBank Nucleotide #
NM_020884.4
NCBI Official Full Name
myosin-7B
NCBI Official Synonym Full Names
myosin heavy chain 7B
NCBI Official Symbol
MYH7B
NCBI Official Synonym Symbols
MHC14; MYH14
UniProt Protein Name
Myosin-7B
UniProt Synonym Protein Names
Antigen MLAA-21; Myosin cardiac muscle beta chain; Myosin heavy chain 7B, cardiac muscle beta isoform; Slow A MYH14
Protein Family
Myosin
UniProt Gene Name
MYH7B
UniProt Synonym Gene Names
KIAA1512
NCBI Protein Information
myosin-7B

NCBI Summary for MYH7B

The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010]
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UniProt Comments for MYH7B

MYH7B: Involved in muscle contraction. Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Contractile; Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: membrane

Molecular Function: actin binding; ATP binding; motor activity; protein binding
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Research Articles on MYH7B

1. Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy. [MYH7B]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MYH7B antibody

 Products by Pathway  Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
 Translocation Of GLUT4 To The Plasma Membrane Pathway antibodies  Translocation Of GLUT4 To The Plasma Membrane Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram

Diseases associated with anti-MYH7B antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >6 publications with MYH7B and Cardiovascular Diseases
 Heart Diseases Antibodies  >6 publications with MYH7B and Heart Diseases
 Hypertrophy Antibodies  >5 publications with MYH7B and Hypertrophy
 Neurologic Manifestations Antibodies  >1 publications with MYH7B and Neurologic Manifestations
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with MYH7B and Prenatal Exposure Delayed Effects
 Fibrosis Antibodies  >1 publications with MYH7B and Fibrosis

Organs/Tissues associated with anti-MYH7B antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >21 publications with MYH7B and Muscle
 Heart Antibodies  >15 publications with MYH7B and Heart
 Embryonic Tissue Antibodies  >5 publications with MYH7B and Embryonic Tissue
 Brain Antibodies  >5 publications with MYH7B and Brain
 Skin Antibodies  >2 publications with MYH7B and Skin
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