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Tau-Protein Kinase 1 (tPK1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2032711
SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment

MBS2032711 is an antibody targeting tPK1. Also known as Tau-Protein Kinase 1 (tPK1) Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tau-Protein Kinase 1 (tPK1), Polyclonal Antibody
Full Product Name
Tau-Protein Kinase 1 (tPK1) Polyclonal Antibody
Product Gene Name
anti-tPK1 antibody
Product Synonym Names
TTBK1; BDTK; TTK; Cdk5/P20; CDK5/P23; GSK; STK31; Brain-derived tau kinase; Tau-Tubulin Kinase 1; Tau-Protein O-Hosphotransferase; Brain Protein Kinase PK40erk
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
0.57mg/ml (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.

Stability Test:
thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: tPK1 (MBS2032711)
Immunogen: tPK1 (MBS2033252)
Matching Pairs
Unconjugated Antibody: tPK1 (MBS2032711)
APC-CY7 Conjugated Antibody: tPK1 (MBS2061544)
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3D Structure
ModBase 3D Structure for Q5TCY1
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Organism Species
Homo sapiens (Human)
Source
Polyclonal antibody preparation
Cross Reactivity
Human
Traits
Liquid
Immunogen
Recombinant tPK1 (Trp34~Arg300) expressed in E.coli (MBS2033252).
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-tPK1 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, Immunoprecipitation (IP).
Application Notes for anti-tPK1 antibody
Western blotting: 0.5-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-tPK1 antibody

Western Blot: Sample: Recombinant tPK1, Human.
Rabbit Anti-tPK1 Polyclonal Antibody – Cat# MBS2032711

Immunohistochemistry (IHC) of anti-tPK1 antibody

DAB staining on IHC-P; Samples: Human Cerebrum Tissue.
Rabbit Anti-tPK1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2032711

Immunohistochemistry (IHC) of anti-tPK1 antibody

DAB staining on IHC-P
Samples: Human Glioma Tissue
Primary Ab: 10ug/ml Rabbit Anti-Human tPK1 Antibody
Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-tPK1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2032711

Other Notes

Small volumes of anti-tPK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for tPK1. It may not necessarily be applicable to this product.

NCBI GI #
58761548
NCBI GeneID
84630
NCBI Accession #
NP_115927.1
UniProt Primary Accession #
Q5TCY1
UniProt Secondary Accession #
Q2L6C6; Q6ZNH0; Q8N444; Q96JH2; A2A2U5
UniProt Related Accession #
Q5TCY1
GenBank Nucleotide #
NM_032538.2
NCBI Official Full Name
tau-tubulin kinase 1
NCBI Official Synonym Full Names
tau tubulin kinase 1
NCBI Official Symbol
TTBK1
NCBI Official Synonym Symbols
BDTK
UniProt Protein Name
Tau-tubulin kinase 1
UniProt Synonym Protein Names
Brain-derived tau kinase
Protein Family
cAMP-dependent protein kinase
UniProt Gene Name
TTBK1
UniProt Synonym Gene Names
BDTK; KIAA1855
NCBI Protein Information
tau-tubulin kinase 1

NCBI Summary for tPK1

Summary:This gene belongs to the casein kinase 1 superfamily. The encoded protein is a neuron-specific, serine/threonine and tyrosine kinase, which regulates phosphorylation of tau, a protein that associates with microtubule assemblies and stabilizes them. Genetic variants in this gene are associated with Alzheimer's disease. [provided by RefSeq, Jul 2016]
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UniProt Comments for tPK1

TTBK1: Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: CK1 group; EC 2.7.11.1; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); TTBK family

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; perinuclear region of cytoplasm; tubulin complex

Molecular Function: ATP binding; protein serine/threonine kinase activity

Biological Process: learning and/or memory; negative regulation of gene expression; negative regulation of protein binding; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of astrocyte activation; positive regulation of cyclin-dependent protein kinase activity; positive regulation of cysteine-type endopeptidase activity; positive regulation of gene expression; positive regulation of microglial cell activation; positive regulation of protein polymerization; protein amino acid phosphorylation; regulation of cell shape; substantia nigra development
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Research Articles on tPK1

1. TTBK1/2 kinases may represent attractive targets for therapeutic intervention for TDP-43 proteinopathies such as Amyotrophic lateral sclerosis and Frontotemporal lobar degeneration-TDP.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-tPK1 antibody

 Reference Product  PubMed Publications
 TTBK2 antibody  >4 publications with tPK1 and TTBK2

Diseases associated with anti-tPK1 antibody

 Disease Name  Pubmed Publications
 Neurodegenerative Diseases Antibodies  >7 publications with tPK1 and Neurodegenerative Diseases
 Tauopathies Antibodies  >6 publications with tPK1 and Tauopathies
 Motor Neuron Disease Antibodies  >2 publications with tPK1 and Motor Neuron Disease
 Death Antibodies  >1 publications with tPK1 and Death
 Neurobehavioral Manifestations Antibodies  >1 publications with tPK1 and Neurobehavioral Manifestations

Organs/Tissues associated with anti-tPK1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with tPK1 and Brain
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